Increased immunogen valency improves the maturation of vaccine-elicited HIV-1 VRC01-like antibodies.

Increased immunogen valency improves the maturation of vaccine-elicited HIV-1 VRC01-like antibodies.

Antibodies belonging to the VRC01-class display broad and potent neutralizing activities and have been isolated from several people living with HIV (PLWH). A member of that class, monoclonal antibody VRC01, was shown to reduce HIV-acquisition in two phase 2b efficacy trials. VRC01-class antibodies a...

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Main Authors: Parul Agrawal, Arineh Khechaduri, Kelsey R Salladay, Anna MacCamy, Duncan K Ralph, Andrew Riker, Andrew B Stuart, Latha Kallur Siddaramaiah, Xiaoying Shen, Frederick A Matsen, David Montefiori, Leonidas Stamatatos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013039
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