Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage
It has been twenty years since the first paper reporting the association between thyroid antibodies (TAIs) and spontaneous miscarriage was published. Following this observation, several studies have clearly demonstrated an increased prevalence of TAI in patients with recurrent miscarriage (RM). Howe...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/717185 |
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| author | Natalia Lazzarin Costanzo Moretti Giovanna De Felice Elena Vaquero Dario Manfellotto |
| author_facet | Natalia Lazzarin Costanzo Moretti Giovanna De Felice Elena Vaquero Dario Manfellotto |
| author_sort | Natalia Lazzarin |
| collection | DOAJ |
| description | It has been twenty years since the first paper reporting the association between thyroid antibodies (TAIs) and spontaneous miscarriage was published. Following this observation, several studies have clearly demonstrated an increased prevalence of TAI in patients with recurrent miscarriage (RM). However, the exact mechanism underlying this association remains a matter of debate. The aim of the present study was to evaluate the thyroid function, throughout a specific test, in patient with RM and TAI focusing on the hypothesis that TAI should be an indirect sign of a mild thyroid dysfunction. 46 patients with RM and TAI were included in the study. All patients underwent short TRH stimulation test showing an abnormal response in the vast majority of cases (65%). Normal FT4 and FT3 mean values were found whereas TSH values were in the upper normal range (2.64±1.3 mUI/L). Our data support the hypothesis that in patients with RM the presence of TAI is an indirect sign of a subtle thyroid dysfunction detectable by a specific test. This test give the possibility to identify women with RM in which specific therapeutic approaches could effectively improve the possibility for a successful pregnancy. |
| format | Article |
| id | doaj-art-4790f7991cef400fad26a3e63fa3aec6 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-4790f7991cef400fad26a3e63fa3aec62025-08-20T03:35:58ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/717185717185Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent MiscarriageNatalia Lazzarin0Costanzo Moretti1Giovanna De Felice2Elena Vaquero3Dario Manfellotto4Fatebenefratelli Association for Research (AFaR), Ospedale Fatebenefratelli Isola Tiberina, Lungotevere de' Cenci 5, 00186 Rome, ItalyDepartment of Endocrinology, University of Rome “Tor Vergata”, Ospedale Fatebenefratelli Isola Tiberina, 00186 Rome, ItalyDepartment of Obstetrics and Gynaecology, University of Rome “Tor Vergata”, Ospedale Fatebenefratelli Isola Tiberina, 00186 Rome, ItalyDepartment of Obstetrics and Gynaecology, University of Rome “Tor Vergata”, Ospedale Fatebenefratelli Isola Tiberina, 00186 Rome, ItalyFatebenefratelli Association for Research (AFaR), Ospedale Fatebenefratelli Isola Tiberina, Lungotevere de' Cenci 5, 00186 Rome, ItalyIt has been twenty years since the first paper reporting the association between thyroid antibodies (TAIs) and spontaneous miscarriage was published. Following this observation, several studies have clearly demonstrated an increased prevalence of TAI in patients with recurrent miscarriage (RM). However, the exact mechanism underlying this association remains a matter of debate. The aim of the present study was to evaluate the thyroid function, throughout a specific test, in patient with RM and TAI focusing on the hypothesis that TAI should be an indirect sign of a mild thyroid dysfunction. 46 patients with RM and TAI were included in the study. All patients underwent short TRH stimulation test showing an abnormal response in the vast majority of cases (65%). Normal FT4 and FT3 mean values were found whereas TSH values were in the upper normal range (2.64±1.3 mUI/L). Our data support the hypothesis that in patients with RM the presence of TAI is an indirect sign of a subtle thyroid dysfunction detectable by a specific test. This test give the possibility to identify women with RM in which specific therapeutic approaches could effectively improve the possibility for a successful pregnancy.http://dx.doi.org/10.1155/2012/717185 |
| spellingShingle | Natalia Lazzarin Costanzo Moretti Giovanna De Felice Elena Vaquero Dario Manfellotto Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage International Journal of Endocrinology |
| title | Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage |
| title_full | Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage |
| title_fullStr | Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage |
| title_full_unstemmed | Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage |
| title_short | Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage |
| title_sort | further evidence on the role of thyroid autoimmunity in women with recurrent miscarriage |
| url | http://dx.doi.org/10.1155/2012/717185 |
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