The Role of Toll-Like Receptor Signaling in the Progression of Heart Failure
Medical systems worldwide are being faced with a growing need to understand mechanisms behind the pathogenesis of heart failure (HF) that is considered as a leading cause of morbidity and mortality around the world. Elevated levels of inflammatory mediators have been identified in patients with HF,...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/9874109 |
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| _version_ | 1832558855668629504 |
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| author | Lili Yu Zhiwei Feng |
| author_facet | Lili Yu Zhiwei Feng |
| author_sort | Lili Yu |
| collection | DOAJ |
| description | Medical systems worldwide are being faced with a growing need to understand mechanisms behind the pathogenesis of heart failure (HF) that is considered as a leading cause of morbidity and mortality around the world. Elevated levels of inflammatory mediators have been identified in patients with HF, which are primarily manifestations of innate immune responses mediated by pattern recognition receptors (PRRs). Toll-like receptors (TLRs), which belong to PRRs, are subjected to the release of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) to generate innate immune responses. More and more emerging data indicate that TLR signaling pathway molecules are involved in the progression of HF. Herein, we present new data with regard to the activation of TLRs in the failing heart, focusing on TLR2, TLR3, TLR4, and TLR9, and suggest the potential use of TLRs in target therapy. |
| format | Article |
| id | doaj-art-4790160e54b54f4788415312fd8271a3 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4790160e54b54f4788415312fd8271a32025-02-03T01:31:24ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/98741099874109The Role of Toll-Like Receptor Signaling in the Progression of Heart FailureLili Yu0Zhiwei Feng1School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, ChinaSchool of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, ChinaMedical systems worldwide are being faced with a growing need to understand mechanisms behind the pathogenesis of heart failure (HF) that is considered as a leading cause of morbidity and mortality around the world. Elevated levels of inflammatory mediators have been identified in patients with HF, which are primarily manifestations of innate immune responses mediated by pattern recognition receptors (PRRs). Toll-like receptors (TLRs), which belong to PRRs, are subjected to the release of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) to generate innate immune responses. More and more emerging data indicate that TLR signaling pathway molecules are involved in the progression of HF. Herein, we present new data with regard to the activation of TLRs in the failing heart, focusing on TLR2, TLR3, TLR4, and TLR9, and suggest the potential use of TLRs in target therapy.http://dx.doi.org/10.1155/2018/9874109 |
| spellingShingle | Lili Yu Zhiwei Feng The Role of Toll-Like Receptor Signaling in the Progression of Heart Failure Mediators of Inflammation |
| title | The Role of Toll-Like Receptor Signaling in the Progression of Heart Failure |
| title_full | The Role of Toll-Like Receptor Signaling in the Progression of Heart Failure |
| title_fullStr | The Role of Toll-Like Receptor Signaling in the Progression of Heart Failure |
| title_full_unstemmed | The Role of Toll-Like Receptor Signaling in the Progression of Heart Failure |
| title_short | The Role of Toll-Like Receptor Signaling in the Progression of Heart Failure |
| title_sort | role of toll like receptor signaling in the progression of heart failure |
| url | http://dx.doi.org/10.1155/2018/9874109 |
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