EXPERIENCE OF TREATMENT WITH INHIBITOR OF T-LYMPHOCYTES CO-STIMULATION ABATACEPT IN PATIENT WITH POLYARTICULAR TYPE OF JUVENILE RHEUMATOID ARTHRITIS
The article presents a case report of recurrent clinical course of polyarticular type of juvenile rheumatoid arthritis, which is characterized with rapid development of disability, low quality of life, high index of functional insufficiency, torpid flow. The disease developed with intolerance to met...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2010-07-01
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| Series: | Вопросы современной педиатрии |
| Online Access: | https://vsp.spr-journal.ru/jour/article/view/935 |
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| author | T.M. Bzarova E.I. Alexeeva S.I. Valieva A.M. Chomakhidze K.B. Isaeva A.O. Lisitsyn R.V. Denisova |
| author_facet | T.M. Bzarova E.I. Alexeeva S.I. Valieva A.M. Chomakhidze K.B. Isaeva A.O. Lisitsyn R.V. Denisova |
| author_sort | T.M. Bzarova |
| collection | DOAJ |
| description | The article presents a case report of recurrent clinical course of polyarticular type of juvenile rheumatoid arthritis, which is characterized with rapid development of disability, low quality of life, high index of functional insufficiency, torpid flow. The disease developed with intolerance to metotrexate and presence of contra-indications to blockers of tumor necrotizing factor _. Authors describe successful treatment with inhibitor of T-lymphocytes co-stimulation abatacept. The dose of drug was 10 mg/kg of body weight during 24 weeks. In two weeks after the beginning of treatment pain and exudative lesions in joints were lessened, joint range of motions significantly increased. The quality of life of patient and her family increased in 4 weeks of treatment with abatacept. The drug induced clinical and laboratory remission in 24 weeks.Key words: children, juvenile rheumatoid arthritis, abatacept, treatment.(Voprosy sovremennoi pediatrii — Current Pediatrics. – 2010;9(4):147-154) |
| format | Article |
| id | doaj-art-478f8f2e78b941ecb9eea69593cd591d |
| institution | Kabale University |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2010-07-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-478f8f2e78b941ecb9eea69593cd591d2025-08-20T03:59:52Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352010-07-0194147154936EXPERIENCE OF TREATMENT WITH INHIBITOR OF T-LYMPHOCYTES CO-STIMULATION ABATACEPT IN PATIENT WITH POLYARTICULAR TYPE OF JUVENILE RHEUMATOID ARTHRITIST.M. Bzarova0E.I. Alexeeva1S.I. Valieva2A.M. Chomakhidze3K.B. Isaeva4A.O. Lisitsyn5R.V. Denisova6Scientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowThe article presents a case report of recurrent clinical course of polyarticular type of juvenile rheumatoid arthritis, which is characterized with rapid development of disability, low quality of life, high index of functional insufficiency, torpid flow. The disease developed with intolerance to metotrexate and presence of contra-indications to blockers of tumor necrotizing factor _. Authors describe successful treatment with inhibitor of T-lymphocytes co-stimulation abatacept. The dose of drug was 10 mg/kg of body weight during 24 weeks. In two weeks after the beginning of treatment pain and exudative lesions in joints were lessened, joint range of motions significantly increased. The quality of life of patient and her family increased in 4 weeks of treatment with abatacept. The drug induced clinical and laboratory remission in 24 weeks.Key words: children, juvenile rheumatoid arthritis, abatacept, treatment.(Voprosy sovremennoi pediatrii — Current Pediatrics. – 2010;9(4):147-154)https://vsp.spr-journal.ru/jour/article/view/935 |
| spellingShingle | T.M. Bzarova E.I. Alexeeva S.I. Valieva A.M. Chomakhidze K.B. Isaeva A.O. Lisitsyn R.V. Denisova EXPERIENCE OF TREATMENT WITH INHIBITOR OF T-LYMPHOCYTES CO-STIMULATION ABATACEPT IN PATIENT WITH POLYARTICULAR TYPE OF JUVENILE RHEUMATOID ARTHRITIS Вопросы современной педиатрии |
| title | EXPERIENCE OF TREATMENT WITH INHIBITOR OF T-LYMPHOCYTES CO-STIMULATION ABATACEPT IN PATIENT WITH POLYARTICULAR TYPE OF JUVENILE RHEUMATOID ARTHRITIS |
| title_full | EXPERIENCE OF TREATMENT WITH INHIBITOR OF T-LYMPHOCYTES CO-STIMULATION ABATACEPT IN PATIENT WITH POLYARTICULAR TYPE OF JUVENILE RHEUMATOID ARTHRITIS |
| title_fullStr | EXPERIENCE OF TREATMENT WITH INHIBITOR OF T-LYMPHOCYTES CO-STIMULATION ABATACEPT IN PATIENT WITH POLYARTICULAR TYPE OF JUVENILE RHEUMATOID ARTHRITIS |
| title_full_unstemmed | EXPERIENCE OF TREATMENT WITH INHIBITOR OF T-LYMPHOCYTES CO-STIMULATION ABATACEPT IN PATIENT WITH POLYARTICULAR TYPE OF JUVENILE RHEUMATOID ARTHRITIS |
| title_short | EXPERIENCE OF TREATMENT WITH INHIBITOR OF T-LYMPHOCYTES CO-STIMULATION ABATACEPT IN PATIENT WITH POLYARTICULAR TYPE OF JUVENILE RHEUMATOID ARTHRITIS |
| title_sort | experience of treatment with inhibitor of t lymphocytes co stimulation abatacept in patient with polyarticular type of juvenile rheumatoid arthritis |
| url | https://vsp.spr-journal.ru/jour/article/view/935 |
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