Association of fluoroquinolone resistance with rare quinolone resistance-determining region (QRDR) mutations and protein-quinolone binding affinity (PQBA) in multidrug-resistant Escherichia coli isolated from patients with urinary tract infection

Association of fluoroquinolone resistance with rare quinolone resistance-determining region (QRDR) mutations and protein-quinolone binding affinity (PQBA) in multidrug-resistant Escherichia coli isolated from patients with urinary tract infection

Background: Urinary tract infections (UTIs) caused by Escherichia coli pose significant public health risks, particularly in developing countries like Bangladesh. This study aimed to elucidate resistance patterns among UTI isolates and comprehensively investigate the mutational spectrum and its impa...

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Bibliographic Details
Main Authors: Md Rasel Khan Manik, Israt Dilruba Mishu, Zimam Mahmud, Muntaha Noor Muskan, Sharmin Zaman Emon
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Infection and Public Health
Subjects:
Urinary tract infections
Antimicrobial resistance
Fluoroquinolones
QRDR mutations
PQBA
Online Access:http://www.sciencedirect.com/science/article/pii/S1876034125001157
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