Metabolic-Associated Steatotic Liver Disease: From Molecular Mechanisms to Novel Therapies
Metabolic-associated steatotic liver disease (MASLD) is a burgeoning worldwide burden and is currently the leading indication for a liver transplant. Despite the growing burden of disease, there are few pharmacological treatments available. The underlying molecular mechanisms of the development of M...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/ijh/5580454 |
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| _version_ | 1849424511484559360 |
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| author | John Cooper Parth Patel Joven Tristeza Alexander Yang |
| author_facet | John Cooper Parth Patel Joven Tristeza Alexander Yang |
| author_sort | John Cooper |
| collection | DOAJ |
| description | Metabolic-associated steatotic liver disease (MASLD) is a burgeoning worldwide burden and is currently the leading indication for a liver transplant. Despite the growing burden of disease, there are few pharmacological treatments available. The underlying molecular mechanisms of the development of MASLD are still being elucidated. In this review, we will summarize the known molecular mechanisms in the development of MASLD along with past, current, and future pharmacologic clinical trials. |
| format | Article |
| id | doaj-art-478d1ab6fbf44dca87ef937453776259 |
| institution | Kabale University |
| issn | 2090-3456 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-478d1ab6fbf44dca87ef9374537762592025-08-20T03:30:08ZengWileyInternational Journal of Hepatology2090-34562025-01-01202510.1155/ijh/5580454Metabolic-Associated Steatotic Liver Disease: From Molecular Mechanisms to Novel TherapiesJohn Cooper0Parth Patel1Joven Tristeza2Alexander Yang3Internal MedicineInternal MedicineInternal MedicineInternal MedicineMetabolic-associated steatotic liver disease (MASLD) is a burgeoning worldwide burden and is currently the leading indication for a liver transplant. Despite the growing burden of disease, there are few pharmacological treatments available. The underlying molecular mechanisms of the development of MASLD are still being elucidated. In this review, we will summarize the known molecular mechanisms in the development of MASLD along with past, current, and future pharmacologic clinical trials.http://dx.doi.org/10.1155/ijh/5580454 |
| spellingShingle | John Cooper Parth Patel Joven Tristeza Alexander Yang Metabolic-Associated Steatotic Liver Disease: From Molecular Mechanisms to Novel Therapies International Journal of Hepatology |
| title | Metabolic-Associated Steatotic Liver Disease: From Molecular Mechanisms to Novel Therapies |
| title_full | Metabolic-Associated Steatotic Liver Disease: From Molecular Mechanisms to Novel Therapies |
| title_fullStr | Metabolic-Associated Steatotic Liver Disease: From Molecular Mechanisms to Novel Therapies |
| title_full_unstemmed | Metabolic-Associated Steatotic Liver Disease: From Molecular Mechanisms to Novel Therapies |
| title_short | Metabolic-Associated Steatotic Liver Disease: From Molecular Mechanisms to Novel Therapies |
| title_sort | metabolic associated steatotic liver disease from molecular mechanisms to novel therapies |
| url | http://dx.doi.org/10.1155/ijh/5580454 |
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