Enhancing Monacolin K and GABA Biosynthesis in <i>Monascus pilosus</i> via <i>GAD</i> Overexpression: Multi-Omics Elucidation of Regulatory Mechanisms

Enhancing Monacolin K and GABA Biosynthesis in <i>Monascus pilosus</i> via <i>GAD</i> Overexpression: Multi-Omics Elucidation of Regulatory Mechanisms

<i>Monascus</i> produces various bioactive compounds, including monacolin K (MK), γ-aminobutyric acid (GABA), and <i>Monascus</i> pigments (MPs). Studies have shown that overexpressing genes within the MK biosynthetic cluster significantly enhances MK production. Additionally...

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Bibliographic Details
Main Authors: Wenlan Mo, Yiyang Cai, Simei Huang, Lishi Xiao, Yanfang Ye, Bin Yang, Chan Zhang, Zhiwei Huang
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Journal of Fungi
Subjects:
<i>Monascus pilosus</i>
<i>Glutamate decarboxylase</i> gene
monacolin K
γ-aminobutyric acid
overexpression
Online Access:https://www.mdpi.com/2309-608X/11/7/506
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