Long-term effects of SARS-CoV-2 infection and vaccination in a population-based pediatric cohort
Abstract During the omicron wave of the COVID-19 pandemic and with SARS-CoV-2 vaccines becoming available, seroprevalence rates rose in children and adolescents. This study investigated the impact of both SARS-CoV-2 infections and vaccinations on the incidence of acute and prolonged symptoms in real...
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Nature Portfolio
2025-01-01
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Online Access: | https://doi.org/10.1038/s41598-024-84140-6 |
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author | Jakob Höppner Christoph Maier Anne Schlegtendal Anna Hoffmann Astrid Petersmann Thomas Lücke Nicole Toepfner Folke Brinkmann |
author_facet | Jakob Höppner Christoph Maier Anne Schlegtendal Anna Hoffmann Astrid Petersmann Thomas Lücke Nicole Toepfner Folke Brinkmann |
author_sort | Jakob Höppner |
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description | Abstract During the omicron wave of the COVID-19 pandemic and with SARS-CoV-2 vaccines becoming available, seroprevalence rates rose in children and adolescents. This study investigated the impact of both SARS-CoV-2 infections and vaccinations on the incidence of acute and prolonged symptoms in real-world conditions during the transition from the pandemic to the endemic phase. Participants from a pediatric population based seroprevalence study (CorKID study) were followed up at least two and for almost four years by survey of health status features and symptoms suggestive of post-COVID syndrome (PCS). In a subgroup (n = 259) SARS-CoV-2 antibody serology was further investigated. 789 participants of the original CorKID study cohort (n = 2.121; 37.2%) were included. 67.9% reported at least one SARS-CoV2 infection. 46.6% had received one or more SARS-CoV-2 vaccinations. In the vast majority of serologically tested participants antibodies again SARS-CoV-2 spike (98.9%) or nucleocapsid (93.3%) antigen were detected following infection and/or vaccination. At least 30% experienced one unrecognized SARS-CoV-2 infection. The overall health status was comparable between children, irrespective of SARS-CoV-2 infections and similar to pre-pandemic assessment. However, a subset of young adolescents exhibited a decline in physical performance compared to pre-pandemic conditions. After infection, PCS-like symptoms persisted in 7% of the respondents for more than three months and up to four years. SARS-CoV-2 vaccinated participants (47%) reported 12% less acute flu-like infections other than SARS-CoV-2. Nearly all participants developed SARS-CoV-2 antibodies in this longitudinal study through either vaccination or infection during the Omicron wave. About 7% of participants suffered from PCS symptoms, predominately fatigue and exhaustion. Furthermore, participants who received vaccinations against SARS-CoV-2 reported a lower frequency of acute infections during follow-up. |
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institution | Kabale University |
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language | English |
publishDate | 2025-01-01 |
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spelling | doaj-art-478549492b3040b59f4a39f891bc1f5f2025-01-26T12:29:52ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-024-84140-6Long-term effects of SARS-CoV-2 infection and vaccination in a population-based pediatric cohortJakob Höppner0Christoph Maier1Anne Schlegtendal2Anna Hoffmann3Astrid Petersmann4Thomas Lücke5Nicole Toepfner6Folke Brinkmann7University Children’s Hospital, St. Josef-Hospital, Ruhr-University BochumUniversity Children’s Hospital, St. Josef-Hospital, Ruhr-University BochumUniversity Children’s Hospital, St. Josef-Hospital, Ruhr-University BochumUniversity Children’s Hospital, St. Josef-Hospital, Ruhr-University BochumInstitute for Clinical Chemistry and Laboratory Medicine, University Medicine OldenburgUniversity Children’s Hospital, St. Josef-Hospital, Ruhr-University BochumDepartment of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität DresdenUniversity Children’s Hospital, St. Josef-Hospital, Ruhr-University BochumAbstract During the omicron wave of the COVID-19 pandemic and with SARS-CoV-2 vaccines becoming available, seroprevalence rates rose in children and adolescents. This study investigated the impact of both SARS-CoV-2 infections and vaccinations on the incidence of acute and prolonged symptoms in real-world conditions during the transition from the pandemic to the endemic phase. Participants from a pediatric population based seroprevalence study (CorKID study) were followed up at least two and for almost four years by survey of health status features and symptoms suggestive of post-COVID syndrome (PCS). In a subgroup (n = 259) SARS-CoV-2 antibody serology was further investigated. 789 participants of the original CorKID study cohort (n = 2.121; 37.2%) were included. 67.9% reported at least one SARS-CoV2 infection. 46.6% had received one or more SARS-CoV-2 vaccinations. In the vast majority of serologically tested participants antibodies again SARS-CoV-2 spike (98.9%) or nucleocapsid (93.3%) antigen were detected following infection and/or vaccination. At least 30% experienced one unrecognized SARS-CoV-2 infection. The overall health status was comparable between children, irrespective of SARS-CoV-2 infections and similar to pre-pandemic assessment. However, a subset of young adolescents exhibited a decline in physical performance compared to pre-pandemic conditions. After infection, PCS-like symptoms persisted in 7% of the respondents for more than three months and up to four years. SARS-CoV-2 vaccinated participants (47%) reported 12% less acute flu-like infections other than SARS-CoV-2. Nearly all participants developed SARS-CoV-2 antibodies in this longitudinal study through either vaccination or infection during the Omicron wave. About 7% of participants suffered from PCS symptoms, predominately fatigue and exhaustion. Furthermore, participants who received vaccinations against SARS-CoV-2 reported a lower frequency of acute infections during follow-up.https://doi.org/10.1038/s41598-024-84140-6SARS-CoV-2ChildrenSeroprevalenceFollow-upVaccination |
spellingShingle | Jakob Höppner Christoph Maier Anne Schlegtendal Anna Hoffmann Astrid Petersmann Thomas Lücke Nicole Toepfner Folke Brinkmann Long-term effects of SARS-CoV-2 infection and vaccination in a population-based pediatric cohort Scientific Reports SARS-CoV-2 Children Seroprevalence Follow-up Vaccination |
title | Long-term effects of SARS-CoV-2 infection and vaccination in a population-based pediatric cohort |
title_full | Long-term effects of SARS-CoV-2 infection and vaccination in a population-based pediatric cohort |
title_fullStr | Long-term effects of SARS-CoV-2 infection and vaccination in a population-based pediatric cohort |
title_full_unstemmed | Long-term effects of SARS-CoV-2 infection and vaccination in a population-based pediatric cohort |
title_short | Long-term effects of SARS-CoV-2 infection and vaccination in a population-based pediatric cohort |
title_sort | long term effects of sars cov 2 infection and vaccination in a population based pediatric cohort |
topic | SARS-CoV-2 Children Seroprevalence Follow-up Vaccination |
url | https://doi.org/10.1038/s41598-024-84140-6 |
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