Role of microRNA in the risk stratification of ischemic strokes
BackgroundIschemic stroke is a major cause of death and morbidity, and risk classification is essential for predicting therapeutic outcomes. MicroRNAs may be useful indicators for risk stratification, as they control gene expression and influence physiological and pathological processes.MethodologyA...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1499493/full |
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| author | Hosam M. Al-Jehani Hosam M. Al-Jehani Hosam M. Al-Jehani Hosam M. Al-Jehani Ahmed Hafez Mousa Ahmed Hafez Mousa Ahmed Hafez Mousa Ahmed Hafez Mousa May Adel Alhamid Fawaz Al-Mufti |
| author_facet | Hosam M. Al-Jehani Hosam M. Al-Jehani Hosam M. Al-Jehani Hosam M. Al-Jehani Ahmed Hafez Mousa Ahmed Hafez Mousa Ahmed Hafez Mousa Ahmed Hafez Mousa May Adel Alhamid Fawaz Al-Mufti |
| author_sort | Hosam M. Al-Jehani |
| collection | DOAJ |
| description | BackgroundIschemic stroke is a major cause of death and morbidity, and risk classification is essential for predicting therapeutic outcomes. MicroRNAs may be useful indicators for risk stratification, as they control gene expression and influence physiological and pathological processes.MethodologyA systematic strategy was developed to search relevant material using databases like PubMed, Scopus, and Web of Science. Selection criteria included human research, a certain date, or categories of studies. Data extraction, synthesis, and analysis were carried out to find trends, similarities, and differences among the chosen studies. The study’s design, sample size, methodology, statistical analysis, and any potential biases or restrictions from the selected reference papers were also taken into account.Results and findingsMicroRNA is an important biomarker for risk stratification in Ischemic Strokes. It can be used to identify Stroke-Specific microRNA Signatures, identify diagnostic and prognostic values, and regulate Vascular Inflammation, Endothelial Dysfunction, and Thrombus Formation and Resolution. It also has potential therapeutic applications.ConclusionMicroRNAs have emerged as promising biomarkers for predicting stroke risk, severity of strokes, and clinical outcomes. They can be used to predict the severity of a stroke and aid clinicians in making treatment decisions. |
| format | Article |
| id | doaj-art-47849ec8e5af42f4babf772f63fe172d |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-47849ec8e5af42f4babf772f63fe172d2025-02-12T05:15:01ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-02-011610.3389/fneur.2025.14994931499493Role of microRNA in the risk stratification of ischemic strokesHosam M. Al-Jehani0Hosam M. Al-Jehani1Hosam M. Al-Jehani2Hosam M. Al-Jehani3Ahmed Hafez Mousa4Ahmed Hafez Mousa5Ahmed Hafez Mousa6Ahmed Hafez Mousa7May Adel Alhamid8Fawaz Al-Mufti9Department of Neurosurgery and Interventional Neuroradiology and Critical Care Medicine, Imam Abdulrahman Bin Faisal University, Al Khobar, Saudi ArabiaDepartment of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, CanadaDepartment of Neurosurgery, Houston Methodist Hospital, Weill Cornell University, Houston, TX, United StatesDepartment of Neurosurgery and Interventional Neuroradiology, King Fahd Hospital Specialist Hospital, Dammam, Saudi ArabiaDepartment of Neurosurgery and Interventional Neuroradiology, King Fahd Hospital Specialist Hospital, Dammam, Saudi ArabiaNeurosciences, Dubai Health, Dubai, United Arab EmiratesDepartment of Neurosurgery, Graduate Medical Education, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab EmiratesDepartment of Neurosurgery and Interventional Neuroradiology, Imam Abdulrahman Bin Faisal University, Al Khobar, Saudi ArabiaDepartment of Neurology and Interventional Neuroradiology, King Fahad Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam, Saudi ArabiaDepartment of Neurology and Neurosurgery, Westchester Medical Center at New York Medical College, Valhalla, NY, United StatesBackgroundIschemic stroke is a major cause of death and morbidity, and risk classification is essential for predicting therapeutic outcomes. MicroRNAs may be useful indicators for risk stratification, as they control gene expression and influence physiological and pathological processes.MethodologyA systematic strategy was developed to search relevant material using databases like PubMed, Scopus, and Web of Science. Selection criteria included human research, a certain date, or categories of studies. Data extraction, synthesis, and analysis were carried out to find trends, similarities, and differences among the chosen studies. The study’s design, sample size, methodology, statistical analysis, and any potential biases or restrictions from the selected reference papers were also taken into account.Results and findingsMicroRNA is an important biomarker for risk stratification in Ischemic Strokes. It can be used to identify Stroke-Specific microRNA Signatures, identify diagnostic and prognostic values, and regulate Vascular Inflammation, Endothelial Dysfunction, and Thrombus Formation and Resolution. It also has potential therapeutic applications.ConclusionMicroRNAs have emerged as promising biomarkers for predicting stroke risk, severity of strokes, and clinical outcomes. They can be used to predict the severity of a stroke and aid clinicians in making treatment decisions.https://www.frontiersin.org/articles/10.3389/fneur.2025.1499493/fullischemic strokemicroRNAsinflammatory responseneuronal deathvascular inflammationendothelial dysfunction |
| spellingShingle | Hosam M. Al-Jehani Hosam M. Al-Jehani Hosam M. Al-Jehani Hosam M. Al-Jehani Ahmed Hafez Mousa Ahmed Hafez Mousa Ahmed Hafez Mousa Ahmed Hafez Mousa May Adel Alhamid Fawaz Al-Mufti Role of microRNA in the risk stratification of ischemic strokes Frontiers in Neurology ischemic stroke microRNAs inflammatory response neuronal death vascular inflammation endothelial dysfunction |
| title | Role of microRNA in the risk stratification of ischemic strokes |
| title_full | Role of microRNA in the risk stratification of ischemic strokes |
| title_fullStr | Role of microRNA in the risk stratification of ischemic strokes |
| title_full_unstemmed | Role of microRNA in the risk stratification of ischemic strokes |
| title_short | Role of microRNA in the risk stratification of ischemic strokes |
| title_sort | role of microrna in the risk stratification of ischemic strokes |
| topic | ischemic stroke microRNAs inflammatory response neuronal death vascular inflammation endothelial dysfunction |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1499493/full |
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