MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations
Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequ...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/4097574 |
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| author | Athanasia Tsaousi Ellen Witte Katrin Witte Hans-Joachim Röwert-Huber Hans-Dieter Volk Wolfram Sterry Kerstin Wolk Sylke Schneider-Burrus Robert Sabat |
| author_facet | Athanasia Tsaousi Ellen Witte Katrin Witte Hans-Joachim Röwert-Huber Hans-Dieter Volk Wolfram Sterry Kerstin Wolk Sylke Schneider-Burrus Robert Sabat |
| author_sort | Athanasia Tsaousi |
| collection | DOAJ |
| description | Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated with metabolic alterations. Here, we demonstrate that one of the most highly upregulated molecules in AI lesions is matrix metalloproteinase 8 (MMP8), an enzyme specialized in the degradation of extracellular matrix components and the HDL component apolipoprotein A-I. Granulocytes, which were present in AI lesions, secreted high amounts of MMP8 especially after TNF-α stimulation. Furthermore, activated fibroblasts but not keratinocytes were found to express MMP8. The high lesional MMP8 levels were accompanied by elevated blood levels that positively correlated with TNF-α blood levels and disease severity assessed by Sartorius score, especially with the number of regions with inflammatory nodules/abscesses and fistulas. Additionally, we found a negative correlation between blood MMP8 and HDL-cholesterol levels, suggesting a contributory role of MMP8 in metabolic alterations in AI. In summary, we demonstrate elevated MMP8 levels in AI lesions, suggest their role in skin destruction and metabolic alterations, and recommend the use of MMP8 as blood biomarker for AI disease activity assessment. |
| format | Article |
| id | doaj-art-47844aac5be04fbfa1e590c230609030 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-47844aac5be04fbfa1e590c2306090302025-02-03T01:10:14ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/40975744097574MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic AlterationsAthanasia Tsaousi0Ellen Witte1Katrin Witte2Hans-Joachim Röwert-Huber3Hans-Dieter Volk4Wolfram Sterry5Kerstin Wolk6Sylke Schneider-Burrus7Robert Sabat8Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charité, Berlin, GermanyInterdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charité, Berlin, GermanyInterdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charité, Berlin, GermanyDepartment of Dermatology and Allergy, University Hospital Charité, Berlin, GermanyBerlin-Brandenburg Center for Regenerative Therapies, University Hospital Charité, Berlin, GermanyDepartment of Dermatology and Allergy, University Hospital Charité, Berlin, GermanyInterdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charité, Berlin, GermanyDepartment of Dermatology and Allergy, University Hospital Charité, Berlin, GermanyInterdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charité, Berlin, GermanyAcne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated with metabolic alterations. Here, we demonstrate that one of the most highly upregulated molecules in AI lesions is matrix metalloproteinase 8 (MMP8), an enzyme specialized in the degradation of extracellular matrix components and the HDL component apolipoprotein A-I. Granulocytes, which were present in AI lesions, secreted high amounts of MMP8 especially after TNF-α stimulation. Furthermore, activated fibroblasts but not keratinocytes were found to express MMP8. The high lesional MMP8 levels were accompanied by elevated blood levels that positively correlated with TNF-α blood levels and disease severity assessed by Sartorius score, especially with the number of regions with inflammatory nodules/abscesses and fistulas. Additionally, we found a negative correlation between blood MMP8 and HDL-cholesterol levels, suggesting a contributory role of MMP8 in metabolic alterations in AI. In summary, we demonstrate elevated MMP8 levels in AI lesions, suggest their role in skin destruction and metabolic alterations, and recommend the use of MMP8 as blood biomarker for AI disease activity assessment.http://dx.doi.org/10.1155/2016/4097574 |
| spellingShingle | Athanasia Tsaousi Ellen Witte Katrin Witte Hans-Joachim Röwert-Huber Hans-Dieter Volk Wolfram Sterry Kerstin Wolk Sylke Schneider-Burrus Robert Sabat MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations Mediators of Inflammation |
| title | MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations |
| title_full | MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations |
| title_fullStr | MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations |
| title_full_unstemmed | MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations |
| title_short | MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations |
| title_sort | mmp8 is increased in lesions and blood of acne inversa patients a potential link to skin destruction and metabolic alterations |
| url | http://dx.doi.org/10.1155/2016/4097574 |
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