Precise engineering of gene expression by editing plasticity

Precise engineering of gene expression by editing plasticity

Abstract Background Identifying transcriptional cis-regulatory elements (CREs) and understanding their role in gene expression are essential for the precise manipulation of gene expression and associated phenotypes. This knowledge is fundamental for advancing genetic engineering and improving crop t...

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Main Authors: Yang Qiu, Lifen Liu, Jiali Yan, Xianglei Xiang, Shouzhe Wang, Yun Luo, Kaixuan Deng, Jieting Xu, Minliang Jin, Xiaoyu Wu, Liwei Cheng, Ying Zhou, Weibo Xie, Hai-Jun Liu, Alisdair R. Fernie, Xuehai Hu, Jianbing Yan
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Genome Biology
Subjects:
CRE
Deep learning
UMI-STARR-seq
Precise regulation
Insilico editing scheme
Editing plasticity
Online Access:https://doi.org/10.1186/s13059-025-03516-7
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