A single-cell transcriptomic atlas of human lens epithelium: identification and functional insights into lens stem/progenitor cells

A single-cell transcriptomic atlas of human lens epithelium: identification and functional insights into lens stem/progenitor cells

Abstract Background The existence of stem/progenitor cells in the lens epithelium has been demonstrated, but their identification remains challenging. Accurate identification requires advanced technologies and a comprehensive understanding of lens epithelial cell (LEC) subtypes, presenting a signifi...

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Main Authors: Yuzhou Gu, Lu Chen, Shuying Chen, Yuhao Wu, Shengjie Hao, Feiyin Sheng, Jiali Yuan, Zhenwei Qin, Di Wu, Yu Han, Zengying Yao, Zhijian Chen, I. Michael Wormstone, Yibo Yu, Junbin Qian, Qiuli Fu, Ke Yao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
scRNA-seq
Aging
Lens epithelial cell
Transient amplifying cell
Lens stem cell
Online Access:https://doi.org/10.1186/s13287-025-04436-w
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