Rotigotine Objectively Improves Sleep in Parkinson’s Disease: An Open-Label Pilot Study with Actigraphic Recording
Sleep disturbances represent important predictors of poor quality of life (QoL) in Parkinson’s disease (PD). This open-label pilot study aimed to objectively assess, by means of actigraphic recording, effect of rotigotine on sleep in PD patients with self-reported sleep complaints. 15 PD patients un...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2016/3724148 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560863606734848 |
|---|---|
| author | Giovanna Calandra-Buonaura Pietro Guaraldi Andrea Doria Stefano Zanigni Stefania Nassetti Valentina Favoni Sabina Cevoli Federica Provini Pietro Cortelli |
| author_facet | Giovanna Calandra-Buonaura Pietro Guaraldi Andrea Doria Stefano Zanigni Stefania Nassetti Valentina Favoni Sabina Cevoli Federica Provini Pietro Cortelli |
| author_sort | Giovanna Calandra-Buonaura |
| collection | DOAJ |
| description | Sleep disturbances represent important predictors of poor quality of life (QoL) in Parkinson’s disease (PD). This open-label pilot study aimed to objectively assess, by means of actigraphic recording, effect of rotigotine on sleep in PD patients with self-reported sleep complaints. 15 PD patients underwent one-week actigraphic recording before (T0) and during (T1) rotigotine treatment, which was titrated to the dose subjectively improving motor symptoms (4–8 mg/24 h). Sleep disturbances, daytime sleepiness, cognitive performance, QoL, and depression were also evaluated with questionnaires. Actigraphic recordings showed a significant reduction in nocturnal motor activity and mean duration of wake episodes after sleep onset during rotigotine treatment compared to baseline. In 10 patients presenting objective evidence of poor sleep quality at T0 (sleep efficiency ≤ 85%), rotigotine also significantly improved other sleep parameters and further reduced nocturnal motor activity and mean duration of wake episodes. A significant decrease in number and duration of daytime sleep episodes was also observed at T1. Finally we confirmed that rotigotine significantly improves perceived sleep quality and QoL. Our study showed for the first time that rotigotine is associated with an objective improvement of nocturnal and diurnal sleep disturbances in PD patients with self-reported sleep complaints. This study is registered with AIFA-observational study registry number 12021. |
| format | Article |
| id | doaj-art-4772471843f8462ab1713ff46d8c88cb |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-4772471843f8462ab1713ff46d8c88cb2025-02-03T01:26:28ZengWileyParkinson's Disease2090-80832042-00802016-01-01201610.1155/2016/37241483724148Rotigotine Objectively Improves Sleep in Parkinson’s Disease: An Open-Label Pilot Study with Actigraphic RecordingGiovanna Calandra-Buonaura0Pietro Guaraldi1Andrea Doria2Stefano Zanigni3Stefania Nassetti4Valentina Favoni5Sabina Cevoli6Federica Provini7Pietro Cortelli8IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, 40139 Bologna, ItalyNeurology Outpatient Clinic, Department of Primary Care, Local Health Authority of Modena, Modena, ItalyDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40123 Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40123 Bologna, ItalyIRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, 40139 Bologna, ItalyIRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, 40139 Bologna, ItalyIRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, 40139 Bologna, ItalyIRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, 40139 Bologna, ItalyIRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, 40139 Bologna, ItalySleep disturbances represent important predictors of poor quality of life (QoL) in Parkinson’s disease (PD). This open-label pilot study aimed to objectively assess, by means of actigraphic recording, effect of rotigotine on sleep in PD patients with self-reported sleep complaints. 15 PD patients underwent one-week actigraphic recording before (T0) and during (T1) rotigotine treatment, which was titrated to the dose subjectively improving motor symptoms (4–8 mg/24 h). Sleep disturbances, daytime sleepiness, cognitive performance, QoL, and depression were also evaluated with questionnaires. Actigraphic recordings showed a significant reduction in nocturnal motor activity and mean duration of wake episodes after sleep onset during rotigotine treatment compared to baseline. In 10 patients presenting objective evidence of poor sleep quality at T0 (sleep efficiency ≤ 85%), rotigotine also significantly improved other sleep parameters and further reduced nocturnal motor activity and mean duration of wake episodes. A significant decrease in number and duration of daytime sleep episodes was also observed at T1. Finally we confirmed that rotigotine significantly improves perceived sleep quality and QoL. Our study showed for the first time that rotigotine is associated with an objective improvement of nocturnal and diurnal sleep disturbances in PD patients with self-reported sleep complaints. This study is registered with AIFA-observational study registry number 12021.http://dx.doi.org/10.1155/2016/3724148 |
| spellingShingle | Giovanna Calandra-Buonaura Pietro Guaraldi Andrea Doria Stefano Zanigni Stefania Nassetti Valentina Favoni Sabina Cevoli Federica Provini Pietro Cortelli Rotigotine Objectively Improves Sleep in Parkinson’s Disease: An Open-Label Pilot Study with Actigraphic Recording Parkinson's Disease |
| title | Rotigotine Objectively Improves Sleep in Parkinson’s Disease: An Open-Label Pilot Study with Actigraphic Recording |
| title_full | Rotigotine Objectively Improves Sleep in Parkinson’s Disease: An Open-Label Pilot Study with Actigraphic Recording |
| title_fullStr | Rotigotine Objectively Improves Sleep in Parkinson’s Disease: An Open-Label Pilot Study with Actigraphic Recording |
| title_full_unstemmed | Rotigotine Objectively Improves Sleep in Parkinson’s Disease: An Open-Label Pilot Study with Actigraphic Recording |
| title_short | Rotigotine Objectively Improves Sleep in Parkinson’s Disease: An Open-Label Pilot Study with Actigraphic Recording |
| title_sort | rotigotine objectively improves sleep in parkinson s disease an open label pilot study with actigraphic recording |
| url | http://dx.doi.org/10.1155/2016/3724148 |
| work_keys_str_mv | AT giovannacalandrabuonaura rotigotineobjectivelyimprovessleepinparkinsonsdiseaseanopenlabelpilotstudywithactigraphicrecording AT pietroguaraldi rotigotineobjectivelyimprovessleepinparkinsonsdiseaseanopenlabelpilotstudywithactigraphicrecording AT andreadoria rotigotineobjectivelyimprovessleepinparkinsonsdiseaseanopenlabelpilotstudywithactigraphicrecording AT stefanozanigni rotigotineobjectivelyimprovessleepinparkinsonsdiseaseanopenlabelpilotstudywithactigraphicrecording AT stefanianassetti rotigotineobjectivelyimprovessleepinparkinsonsdiseaseanopenlabelpilotstudywithactigraphicrecording AT valentinafavoni rotigotineobjectivelyimprovessleepinparkinsonsdiseaseanopenlabelpilotstudywithactigraphicrecording AT sabinacevoli rotigotineobjectivelyimprovessleepinparkinsonsdiseaseanopenlabelpilotstudywithactigraphicrecording AT federicaprovini rotigotineobjectivelyimprovessleepinparkinsonsdiseaseanopenlabelpilotstudywithactigraphicrecording AT pietrocortelli rotigotineobjectivelyimprovessleepinparkinsonsdiseaseanopenlabelpilotstudywithactigraphicrecording |