Pharmacokinetics modulation in solid tumors through thrombin-embedded nanomedicine

Pharmacokinetics modulation in solid tumors through thrombin-embedded nanomedicine

Abstract The development of anti-tumor nanomedicines grapples with the critical challenge of achieving sustained retention and massive intratumoral distributions of chemotherapeutics. Herein, we attempted multifaceted prodrug nanomedicine with precise spatiotemporal responsiveness, integrating dual...

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Bibliographic Details
Main Authors: Sheng Lin, Liuwei Zhang, Hongyan Cui, Yue Wang, Yang Zheng, Jianhua Hu, Mingzhu Li, Wentao Wang, Shijia Zhang, Kehui Zhou, Qixian Chen, Xiabin Lan, Yan Zhao
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Nanobiotechnology
Subjects:
Solid tumor
Nanomedicine
Targeted drug delivery
Prodrug nanomedicine
Tumor microenvironment-responsive
Synergistic anticancer therapy
Online Access:https://doi.org/10.1186/s12951-025-03302-4
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