Overexpression of blaSHV-12 caused by tandem amplification contributed to ceftazidime/avibactam resistance in hypervirulent and carbapenem-resistant Klebsiella pneumoniae

Overexpression of blaSHV-12 caused by tandem amplification contributed to ceftazidime/avibactam resistance in hypervirulent and carbapenem-resistant Klebsiella pneumoniae

We identified a novel ceftazidime/avibactam (CAZ/AVI) resistance mechanism in endemic sequence type 11 hypervirulent and carbapenem-resistant Klebsiella pneumoniae isolated from a patient who had not been exposed CAZ/AVI. Overexpression of blaSHV-12 caused by tandem gene amplification contributed to...

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Bibliographic Details
Main Authors: Chao Liu, Juan Yi, Ping Yang, Chunjing Du, Fan Jiang, Ming Lu, Pengcheng Du, Ning Shen
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
Hypervirulent klebsiella pneumoniae
ceftazidime/avibactam resistance
blaSHV-12
sequence type 11
gene amplification
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2024.2426481
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