Efficacy and safety of local lysozyme treatment in patients with oral mucositis after chemotherapy and radiotherapy
This observational clinical study was composed of two substudies: a non-comparative one (n = 166), testing only lysozyme-based compounds (LBCs), and a comparative substudy (n = 275), testing both LBCs and bicarbonate-based local compounds (BBCs) on the healing of oral mucositis during radio- or chem...
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| Format: | Article |
| Language: | English |
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Sciendo
2019-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2019-0053 |
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| author | Eminagić Dzenana Lokvančić Aida Hasanbegović Berisa Mekić-Abazović Alma Avdičević Asmir Marijanović Inga Janković Slobodan M. Kapo Belma |
| author_facet | Eminagić Dzenana Lokvančić Aida Hasanbegović Berisa Mekić-Abazović Alma Avdičević Asmir Marijanović Inga Janković Slobodan M. Kapo Belma |
| author_sort | Eminagić Dzenana |
| collection | DOAJ |
| description | This observational clinical study was composed of two substudies: a non-comparative one (n = 166), testing only lysozyme-based compounds (LBCs), and a comparative substudy (n = 275), testing both LBCs and bicarbonate-based local compounds (BBCs) on the healing of oral mucositis during radio- or chemotherapy. The density of ulcerations has decreased significantly after the treatment with lysozyme in both substudies. The density of ulcerations in the radiotherapy group was lower in patients treated with LBCs compared to patients treated with BBCs (p < 0.001). In the chemotherapy group, reduction of ulceration density was similar with both LBCs and BBCs. The LBCs reduced pain intensity during the intake of solid food and speech more than BBCs in both patient cohorts (p < 0.05). In the radiotherapy cohort, pain intensity when consuming liquid foods was reduced more with LBCs than with BBCs (p < 0.05). No adverse events were recorded. This study demonstrates the advantages of treating oral mucositis during radiotherapy or chemo-therapy with LBCs. |
| format | Article |
| id | doaj-art-476b2b0907d74058a897878e3ec549a3 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-476b2b0907d74058a897878e3ec549a32025-02-02T15:22:05ZengSciendoActa Pharmaceutica1846-95582019-12-0169469570410.2478/acph-2019-0053acph-2019-0053Efficacy and safety of local lysozyme treatment in patients with oral mucositis after chemotherapy and radiotherapyEminagić Dzenana0Lokvančić Aida1Hasanbegović Berisa2Mekić-Abazović Alma3Avdičević Asmir4Marijanović Inga5Janković Slobodan M.6Kapo Belma7Clinical Center University of SarajevoBosnia and HerzegovinaBosnalijek JSC, Sarajevo, Bosnia and HerzegovinaClinical Center University of SarajevoBosnia and HerzegovinaZenica Cantonal Hospital, Bosnia and HerzegovinaUniversity Clinical Center Tuzla, Bosnia and HerzegovinaUniversity Hospital Mostar, Bosnia and HerzegovinaUniversity of Kragujevac, Faculty of Medical Sciences, SerbiaBosnalijek JSC, Sarajevo, Bosnia and HerzegovinaThis observational clinical study was composed of two substudies: a non-comparative one (n = 166), testing only lysozyme-based compounds (LBCs), and a comparative substudy (n = 275), testing both LBCs and bicarbonate-based local compounds (BBCs) on the healing of oral mucositis during radio- or chemotherapy. The density of ulcerations has decreased significantly after the treatment with lysozyme in both substudies. The density of ulcerations in the radiotherapy group was lower in patients treated with LBCs compared to patients treated with BBCs (p < 0.001). In the chemotherapy group, reduction of ulceration density was similar with both LBCs and BBCs. The LBCs reduced pain intensity during the intake of solid food and speech more than BBCs in both patient cohorts (p < 0.05). In the radiotherapy cohort, pain intensity when consuming liquid foods was reduced more with LBCs than with BBCs (p < 0.05). No adverse events were recorded. This study demonstrates the advantages of treating oral mucositis during radiotherapy or chemo-therapy with LBCs.https://doi.org/10.2478/acph-2019-0053oral mucositistreatment efficacyradiotherapychemotherapytopicallysozyme |
| spellingShingle | Eminagić Dzenana Lokvančić Aida Hasanbegović Berisa Mekić-Abazović Alma Avdičević Asmir Marijanović Inga Janković Slobodan M. Kapo Belma Efficacy and safety of local lysozyme treatment in patients with oral mucositis after chemotherapy and radiotherapy Acta Pharmaceutica oral mucositis treatment efficacy radiotherapy chemotherapy topical lysozyme |
| title | Efficacy and safety of local lysozyme treatment in patients with oral mucositis after chemotherapy and radiotherapy |
| title_full | Efficacy and safety of local lysozyme treatment in patients with oral mucositis after chemotherapy and radiotherapy |
| title_fullStr | Efficacy and safety of local lysozyme treatment in patients with oral mucositis after chemotherapy and radiotherapy |
| title_full_unstemmed | Efficacy and safety of local lysozyme treatment in patients with oral mucositis after chemotherapy and radiotherapy |
| title_short | Efficacy and safety of local lysozyme treatment in patients with oral mucositis after chemotherapy and radiotherapy |
| title_sort | efficacy and safety of local lysozyme treatment in patients with oral mucositis after chemotherapy and radiotherapy |
| topic | oral mucositis treatment efficacy radiotherapy chemotherapy topical lysozyme |
| url | https://doi.org/10.2478/acph-2019-0053 |
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