Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary Intervention
The consumption of low-alcohol fermented beverages has been related to cardiovascular health improvements. Although the underlying mechanism is not completely understood, (poly)phenols have been proposed as one of the mediators. The objective of this study was to evaluate the impact of a controlled...
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2025-07-01
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| author | Daniel Hinojosa-Nogueira Cristina María Díaz-Perdigones María José García-López Ascensión Marcos María P. Portillo Rosa María Lamuela-Raventós Alba Subiri-Verdugo Esther Nova Iñaki Milton-Laskibar Polina Galkina Francisco J. Tinahones Isabel Moreno-Indias |
| author_facet | Daniel Hinojosa-Nogueira Cristina María Díaz-Perdigones María José García-López Ascensión Marcos María P. Portillo Rosa María Lamuela-Raventós Alba Subiri-Verdugo Esther Nova Iñaki Milton-Laskibar Polina Galkina Francisco J. Tinahones Isabel Moreno-Indias |
| author_sort | Daniel Hinojosa-Nogueira |
| collection | DOAJ |
| description | The consumption of low-alcohol fermented beverages has been related to cardiovascular health improvements. Although the underlying mechanism is not completely understood, (poly)phenols have been proposed as one of the mediators. The objective of this study was to evaluate the impact of a controlled intervention with beer on (poly)phenols metabolism in individuals with and without metabolic syndrome (MetS). 20 participants (MetS and control) who consumed a standardized amount of beer during 6 weeks were recruited. Phenolic compounds were assessed in urine. Different changes in phenolic compounds associated with chronic beer consumption were found, particularly related to hesperetin conjugates and to the degradation of phenolic compounds derived from flavonoids and lignans. Noteworthily, MetS and control participants differed in baseline urine phenolic compound profiles and in their metabolization. Significant differences were found in the production and excretion of key (poly)phenols-derived metabolites, such as increased naringenin phase II conjugates in healthy subjects, or increased bacterial flavonoid catabolites. Certain relationships were observed between the phenolic compounds with metabolic and anthropometric variables. These findings suggest that beer-derived (poly)phenols are differentially metabolized according to metabolic-health status, and that they may contribute to certain metabolic health benefits through the modulation of specific metabolic pathways. |
| format | Article |
| id | doaj-art-47684bbf72754fa88a96e018e2aa8463 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-47684bbf72754fa88a96e018e2aa84632025-08-20T03:56:49ZengMDPI AGMolecules1420-30492025-07-013014293210.3390/molecules30142932Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary InterventionDaniel Hinojosa-Nogueira0Cristina María Díaz-Perdigones1María José García-López2Ascensión Marcos3María P. Portillo4Rosa María Lamuela-Raventós5Alba Subiri-Verdugo6Esther Nova7Iñaki Milton-Laskibar8Polina Galkina9Francisco J. Tinahones10Isabel Moreno-Indias11Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina—IBIMA Plataforma, BIONAND, 29590 Málaga, SpainInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina—IBIMA Plataforma, BIONAND, 29590 Málaga, SpainInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina—IBIMA Plataforma, BIONAND, 29590 Málaga, SpainInstitute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), 28040 Madrid, SpainCIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, 28029 Madrid, SpainCIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, 28029 Madrid, SpainInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina—IBIMA Plataforma, BIONAND, 29590 Málaga, SpainInstitute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), 28040 Madrid, SpainCIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, 28029 Madrid, SpainCIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, 28029 Madrid, SpainInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina—IBIMA Plataforma, BIONAND, 29590 Málaga, SpainInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina—IBIMA Plataforma, BIONAND, 29590 Málaga, SpainThe consumption of low-alcohol fermented beverages has been related to cardiovascular health improvements. Although the underlying mechanism is not completely understood, (poly)phenols have been proposed as one of the mediators. The objective of this study was to evaluate the impact of a controlled intervention with beer on (poly)phenols metabolism in individuals with and without metabolic syndrome (MetS). 20 participants (MetS and control) who consumed a standardized amount of beer during 6 weeks were recruited. Phenolic compounds were assessed in urine. Different changes in phenolic compounds associated with chronic beer consumption were found, particularly related to hesperetin conjugates and to the degradation of phenolic compounds derived from flavonoids and lignans. Noteworthily, MetS and control participants differed in baseline urine phenolic compound profiles and in their metabolization. Significant differences were found in the production and excretion of key (poly)phenols-derived metabolites, such as increased naringenin phase II conjugates in healthy subjects, or increased bacterial flavonoid catabolites. Certain relationships were observed between the phenolic compounds with metabolic and anthropometric variables. These findings suggest that beer-derived (poly)phenols are differentially metabolized according to metabolic-health status, and that they may contribute to certain metabolic health benefits through the modulation of specific metabolic pathways.https://www.mdpi.com/1420-3049/30/14/2932beer(poly)phenolsdietary interventionmetabolismmetabolic syndrome |
| spellingShingle | Daniel Hinojosa-Nogueira Cristina María Díaz-Perdigones María José García-López Ascensión Marcos María P. Portillo Rosa María Lamuela-Raventós Alba Subiri-Verdugo Esther Nova Iñaki Milton-Laskibar Polina Galkina Francisco J. Tinahones Isabel Moreno-Indias Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary Intervention Molecules beer (poly)phenols dietary intervention metabolism metabolic syndrome |
| title | Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary Intervention |
| title_full | Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary Intervention |
| title_fullStr | Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary Intervention |
| title_full_unstemmed | Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary Intervention |
| title_short | Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary Intervention |
| title_sort | beer derived poly phenol metabolism in individuals with and without metabolic syndrome a comparative dietary intervention |
| topic | beer (poly)phenols dietary intervention metabolism metabolic syndrome |
| url | https://www.mdpi.com/1420-3049/30/14/2932 |
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