Magnetomotive Displacement of Magnetic Nanoparticles in Different Tissue Phantoms
Magnetic nanoparticles (MNPs) can be used in various biomedical applications, such as magnetic drug targeting (MDT) or magnetic hyperthermia for cancer treatment. MNPs are injected into the body and accumulated with an external magnetic field at the tumor site. For therapy monitoring, the MNPs distr...
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| Format: | Article |
| Language: | English |
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De Gruyter
2024-12-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2024-2079 |
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| author | Huber Christian Marinus Heim Christian Li Jiaqi Ermert Helmut Rupitsch Stefan J. Ullmann Ingrid Lyer Stefan |
| author_facet | Huber Christian Marinus Heim Christian Li Jiaqi Ermert Helmut Rupitsch Stefan J. Ullmann Ingrid Lyer Stefan |
| author_sort | Huber Christian Marinus |
| collection | DOAJ |
| description | Magnetic nanoparticles (MNPs) can be used in various biomedical applications, such as magnetic drug targeting (MDT) or magnetic hyperthermia for cancer treatment. MNPs are injected into the body and accumulated with an external magnetic field at the tumor site. For therapy monitoring, the MNPs distribution has to be accurately mapped in real time. Magnetomotive ultrasound (MMUS) is a suitable technique for this purpose. It was already demonstrated that MMUS can map the accumulation process of MNPs during MDT. Moreover, inverse MMUS is an advanced technique to quantify MNP distribution. This method simulates the displacement of MNPs and surrounding tissues and compares the results to measured data. Understanding how magnetomotive displacement behaves in various elastic environments is crucial for advancing inverse MMUS and accurately quantifying MNP distributions. In this study, ultrasound tissue phantoms were fabricated with varying elastic parameters, incorporating MNPs. Subsequently, their MMUS displacement is assessed. |
| format | Article |
| id | doaj-art-47677e903e9248d28cd56d3cb7c877d6 |
| institution | DOAJ |
| issn | 2364-5504 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj-art-47677e903e9248d28cd56d3cb7c877d62025-08-20T02:51:59ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042024-12-0110432432710.1515/cdbme-2024-2079Magnetomotive Displacement of Magnetic Nanoparticles in Different Tissue PhantomsHuber Christian Marinus0Heim Christian1Li Jiaqi2Ermert Helmut3Rupitsch Stefan J.4Ullmann Ingrid5Lyer Stefan6Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Professorship for AI-Controlled Nanomaterials (KINAM), Universitatsklinikum,Erlangen, GermanyDepartment of Microsystems Engineering (IMTEK), Laboratory for Electrical Instrumentation and Embedded Systems, University of Freiburg,Freiburg, GermanyLHFT, Friedrich-Alexander-Universitat Erlangen-Nurnberg,Erlangen, GermanyDepartment of Otorhinolaryngology, Head and Neck Surgery, SEON, KINAM, Universitatsklinikum Erlangen,Erlangen, GermanyDepartment of Microsystems Engineering (IMTEK), Laboratory for Electrical Instrumentation and Embedded Systems, University of Freiburg,Freiburg, GermanyLHFT, Friedrich-Alexander-Universitat Erlangen-Nurnberg,Erlangen, GermanyDepartment of Otorhinolaryngology, Head and Neck Surgery, SEON, KINAM, Universitatsklinikum Erlangen,Erlangen, GermanyMagnetic nanoparticles (MNPs) can be used in various biomedical applications, such as magnetic drug targeting (MDT) or magnetic hyperthermia for cancer treatment. MNPs are injected into the body and accumulated with an external magnetic field at the tumor site. For therapy monitoring, the MNPs distribution has to be accurately mapped in real time. Magnetomotive ultrasound (MMUS) is a suitable technique for this purpose. It was already demonstrated that MMUS can map the accumulation process of MNPs during MDT. Moreover, inverse MMUS is an advanced technique to quantify MNP distribution. This method simulates the displacement of MNPs and surrounding tissues and compares the results to measured data. Understanding how magnetomotive displacement behaves in various elastic environments is crucial for advancing inverse MMUS and accurately quantifying MNP distributions. In this study, ultrasound tissue phantoms were fabricated with varying elastic parameters, incorporating MNPs. Subsequently, their MMUS displacement is assessed.https://doi.org/10.1515/cdbme-2024-2079ultrasound imagingdisplacement trackingmagnetic nanoparticlesmagnetic drug targeting |
| spellingShingle | Huber Christian Marinus Heim Christian Li Jiaqi Ermert Helmut Rupitsch Stefan J. Ullmann Ingrid Lyer Stefan Magnetomotive Displacement of Magnetic Nanoparticles in Different Tissue Phantoms Current Directions in Biomedical Engineering ultrasound imaging displacement tracking magnetic nanoparticles magnetic drug targeting |
| title | Magnetomotive Displacement of Magnetic Nanoparticles in Different Tissue Phantoms |
| title_full | Magnetomotive Displacement of Magnetic Nanoparticles in Different Tissue Phantoms |
| title_fullStr | Magnetomotive Displacement of Magnetic Nanoparticles in Different Tissue Phantoms |
| title_full_unstemmed | Magnetomotive Displacement of Magnetic Nanoparticles in Different Tissue Phantoms |
| title_short | Magnetomotive Displacement of Magnetic Nanoparticles in Different Tissue Phantoms |
| title_sort | magnetomotive displacement of magnetic nanoparticles in different tissue phantoms |
| topic | ultrasound imaging displacement tracking magnetic nanoparticles magnetic drug targeting |
| url | https://doi.org/10.1515/cdbme-2024-2079 |
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