Lipid signature changes of women with gestational diabetes mellitus in response to puerperal exclusive breastfeeding
ABSTRACT Objective We here investigated whether lactation during puerperium could help to reverse the diabetogenic effect of gestation and further explored the lipid profiling changes upon breastfeeding. Methods Thirty‐five women diagnosed with GDM were recruited, and fasting plasma samples were col...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.14349 |
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| author | Jin He Xiaoxiao Yin Tingting Yu Lu Li Yan Cui Chen Jiang Chengping Qiao Zhijing Miao Xianwei Cui Chenbo Ji |
| author_facet | Jin He Xiaoxiao Yin Tingting Yu Lu Li Yan Cui Chen Jiang Chengping Qiao Zhijing Miao Xianwei Cui Chenbo Ji |
| author_sort | Jin He |
| collection | DOAJ |
| description | ABSTRACT Objective We here investigated whether lactation during puerperium could help to reverse the diabetogenic effect of gestation and further explored the lipid profiling changes upon breastfeeding. Methods Thirty‐five women diagnosed with GDM were recruited, and fasting plasma samples were collected at ~6 weeks postpartum. Maternal metabolic parameters were determined, and an untargeted lipidomic analysis was performed. The relationship between underlying lipidomic responses and lactation was explored. Results Improved glucose homeostasis and insulin sensitivity were observed in GDM women who adopted breastfeeding during the puerperium. Further lipidomics analysis revealed prominent correlations between lipid constitution changes and breastfeeding in women with GDM. A total of 766 lipid species were identified, 33 of which were found to be significantly altered in response to lactation. Significant associations between dysregulated lipids and maternal metabolic parameters were also shown. Subsequently, we identified a panel of three lipids that were strongly associated with breastfeeding, from which we constructed a predictive model with higher discriminating power. Conclusions We generally revealed that lactation during puerperium appears to have favorable effects on diabetogenic risk factors for GDM women. We also discovered that lipidomic changes related to lactation could elucidate the mother's recovery from GDM pregnancy. |
| format | Article |
| id | doaj-art-476281d6ea0d4ed189ad351bf9bfb655 |
| institution | Kabale University |
| issn | 2040-1116 2040-1124 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj-art-476281d6ea0d4ed189ad351bf9bfb6552025-02-01T10:02:01ZengWileyJournal of Diabetes Investigation2040-11162040-11242025-02-0116231532510.1111/jdi.14349Lipid signature changes of women with gestational diabetes mellitus in response to puerperal exclusive breastfeedingJin He0Xiaoxiao Yin1Tingting Yu2Lu Li3Yan Cui4Chen Jiang5Chengping Qiao6Zhijing Miao7Xianwei Cui8Chenbo Ji9Women's Hospital of Nanjing Medical University Nanjing Women and Children's Healthcare Hospital Nanjing Jiangsu ChinaWomen's Hospital of Nanjing Medical University Nanjing Women and Children's Healthcare Hospital Nanjing Jiangsu ChinaWomen's Hospital of Nanjing Medical University Nanjing Women and Children's Healthcare Hospital Nanjing Jiangsu ChinaWomen's Hospital of Nanjing Medical University Nanjing Women and Children's Healthcare Hospital Nanjing Jiangsu ChinaWomen's Hospital of Nanjing Medical University Nanjing Women and Children's Healthcare Hospital Nanjing Jiangsu ChinaDepartment of Obstetrics and Gynecology, Women's Hospital of Nanjing Medical University Nanjing Women and Children's Healthcare Hospital Nanjing Jiangsu ChinaDepartment of Obstetrics and Gynecology, Women's Hospital of Nanjing Medical University Nanjing Women and Children's Healthcare Hospital Nanjing Jiangsu ChinaDepartment of Obstetrics and Gynecology, Women's Hospital of Nanjing Medical University Nanjing Women and Children's Healthcare Hospital Nanjing Jiangsu ChinaWomen's Hospital of Nanjing Medical University Nanjing Women and Children's Healthcare Hospital Nanjing Jiangsu ChinaWomen's Hospital of Nanjing Medical University Nanjing Women and Children's Healthcare Hospital Nanjing Jiangsu ChinaABSTRACT Objective We here investigated whether lactation during puerperium could help to reverse the diabetogenic effect of gestation and further explored the lipid profiling changes upon breastfeeding. Methods Thirty‐five women diagnosed with GDM were recruited, and fasting plasma samples were collected at ~6 weeks postpartum. Maternal metabolic parameters were determined, and an untargeted lipidomic analysis was performed. The relationship between underlying lipidomic responses and lactation was explored. Results Improved glucose homeostasis and insulin sensitivity were observed in GDM women who adopted breastfeeding during the puerperium. Further lipidomics analysis revealed prominent correlations between lipid constitution changes and breastfeeding in women with GDM. A total of 766 lipid species were identified, 33 of which were found to be significantly altered in response to lactation. Significant associations between dysregulated lipids and maternal metabolic parameters were also shown. Subsequently, we identified a panel of three lipids that were strongly associated with breastfeeding, from which we constructed a predictive model with higher discriminating power. Conclusions We generally revealed that lactation during puerperium appears to have favorable effects on diabetogenic risk factors for GDM women. We also discovered that lipidomic changes related to lactation could elucidate the mother's recovery from GDM pregnancy.https://doi.org/10.1111/jdi.14349LactationLipidomicMaternal metabolism |
| spellingShingle | Jin He Xiaoxiao Yin Tingting Yu Lu Li Yan Cui Chen Jiang Chengping Qiao Zhijing Miao Xianwei Cui Chenbo Ji Lipid signature changes of women with gestational diabetes mellitus in response to puerperal exclusive breastfeeding Journal of Diabetes Investigation Lactation Lipidomic Maternal metabolism |
| title | Lipid signature changes of women with gestational diabetes mellitus in response to puerperal exclusive breastfeeding |
| title_full | Lipid signature changes of women with gestational diabetes mellitus in response to puerperal exclusive breastfeeding |
| title_fullStr | Lipid signature changes of women with gestational diabetes mellitus in response to puerperal exclusive breastfeeding |
| title_full_unstemmed | Lipid signature changes of women with gestational diabetes mellitus in response to puerperal exclusive breastfeeding |
| title_short | Lipid signature changes of women with gestational diabetes mellitus in response to puerperal exclusive breastfeeding |
| title_sort | lipid signature changes of women with gestational diabetes mellitus in response to puerperal exclusive breastfeeding |
| topic | Lactation Lipidomic Maternal metabolism |
| url | https://doi.org/10.1111/jdi.14349 |
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