STIM1 signaling modulates invasive phenotypic plasticity by regulating calpain-dependent cleavage of integrin-β4 in nasopharyngeal carcinoma cells

STIM1 signaling modulates invasive phenotypic plasticity by regulating calpain-dependent cleavage of integrin-β4 in nasopharyngeal carcinoma cells

Abstract Background Stromal interaction molecule 1 (STIM1)-mediated Ca2+ signaling modulates the malignant features of nasopharyngeal carcinoma (NPC), a unique Epstein-Barr virus (EBV)-associated human malignancy. Integrin-β4 is involved in EBV-promoted motility in NPC cells. However, the underlying...

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Bibliographic Details
Main Authors: Weiming Deng, Wenlin Huang, Yujuan Huang, Lihong Huang, Linsong Ye, Fei Liu, Min Li, Jingjin Weng, Qian He, Jinyan Zhang, Shenhong Qu, Jiazhang Wei
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cancer Cell International
Subjects:
Integrin-β4
Invasive plasticity
Stromal interaction molecule 1
Nasopharyngeal carcinoma
Online Access:https://doi.org/10.1186/s12935-025-03890-z
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