L-Arginine Intake Effect on Adenine Nucleotide Metabolism in Rat Parenchymal and Reproductive Tissues
L-arginine is conditionally essetcial amino acid, required for normal cell growth, protein synthesis, ammonia detoxification, tissue growth and general performance, proposed in the treatment of men sterility and prevention of male impotence. The aim of the present paper was to estimate the activity...
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2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/208239 |
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| author | G. Kocic J. Nikolic T. Jevtovic-Stoimenov D. Sokolovic H. Kocic T. Cvetkovic D. Pavlovic A. Cencic D. Stojanovic |
| author_facet | G. Kocic J. Nikolic T. Jevtovic-Stoimenov D. Sokolovic H. Kocic T. Cvetkovic D. Pavlovic A. Cencic D. Stojanovic |
| author_sort | G. Kocic |
| collection | DOAJ |
| description | L-arginine is conditionally essetcial amino acid, required for normal cell growth, protein synthesis, ammonia detoxification, tissue growth and general performance, proposed in the treatment of men sterility and prevention of male impotence. The aim of the present paper was to estimate the activity of the enzymes of adenine nucleotide metabolism: 5′-nucleotidase (5′-NU), adenosine deaminase (ADA), AMP deaminase, and xanthine oxidase (XO), during dietary intake of L-arginine for a period of four weeks of male Wistar rats. Adenosine concentration in tissues is maintained by the relative activities of the adenosine-producing enzyme, 5′-NU and the adenosine-degrading enzyme-ADA adenosine deaminase. Dietary L-arginine intake directed adenine nucleotide metabolism in liver, kidney, and testis tissue toward the activation of adenosine production, by increased 5′-NU activity and decreased ADA activity. Stimulation of adenosine accumulation could be of importance in mediating arginine antiatherosclerotic, vasoactive, immunomodulatory, and antioxidant effects. Assuming that the XO activity reflects the rate of purine catabolism in the cell, while the activity of AMP deaminase is of importance in ATP regeneration, reduced activity of XO, together with the increased AMP-deaminase activity, may suggest that adenine nucleotides are presumably directed to the ATP regenerating process during dietary L-arginine intake. |
| format | Article |
| id | doaj-art-474edc0945134b84b8c04e42ff840a52 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-474edc0945134b84b8c04e42ff840a522025-02-03T01:11:01ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/208239208239L-Arginine Intake Effect on Adenine Nucleotide Metabolism in Rat Parenchymal and Reproductive TissuesG. Kocic0J. Nikolic1T. Jevtovic-Stoimenov2D. Sokolovic3H. Kocic4T. Cvetkovic5D. Pavlovic6A. Cencic7D. Stojanovic8Institute of Biochemistry, Faculty of Medicine, University of Nis, Bulevar, Dr Zorana Djindjica 81, 18000 Nis, SerbiaInstitute of Biochemistry, Faculty of Medicine, University of Nis, Bulevar, Dr Zorana Djindjica 81, 18000 Nis, SerbiaInstitute of Biochemistry, Faculty of Medicine, University of Nis, Bulevar, Dr Zorana Djindjica 81, 18000 Nis, SerbiaInstitute of Biochemistry, Faculty of Medicine, University of Nis, Bulevar, Dr Zorana Djindjica 81, 18000 Nis, SerbiaFaculty of Medicine, University of Nis, 18000 Nis, SerbiaInstitute of Biochemistry, Faculty of Medicine, University of Nis, Bulevar, Dr Zorana Djindjica 81, 18000 Nis, SerbiaInstitute of Biochemistry, Faculty of Medicine, University of Nis, Bulevar, Dr Zorana Djindjica 81, 18000 Nis, SerbiaMedical Faculty, University Maribor, 2000 Maribor, SloveniaDepartment of Hygiene, Faculty of Medicine, University of Nis, 18000 Nis, SerbiaL-arginine is conditionally essetcial amino acid, required for normal cell growth, protein synthesis, ammonia detoxification, tissue growth and general performance, proposed in the treatment of men sterility and prevention of male impotence. The aim of the present paper was to estimate the activity of the enzymes of adenine nucleotide metabolism: 5′-nucleotidase (5′-NU), adenosine deaminase (ADA), AMP deaminase, and xanthine oxidase (XO), during dietary intake of L-arginine for a period of four weeks of male Wistar rats. Adenosine concentration in tissues is maintained by the relative activities of the adenosine-producing enzyme, 5′-NU and the adenosine-degrading enzyme-ADA adenosine deaminase. Dietary L-arginine intake directed adenine nucleotide metabolism in liver, kidney, and testis tissue toward the activation of adenosine production, by increased 5′-NU activity and decreased ADA activity. Stimulation of adenosine accumulation could be of importance in mediating arginine antiatherosclerotic, vasoactive, immunomodulatory, and antioxidant effects. Assuming that the XO activity reflects the rate of purine catabolism in the cell, while the activity of AMP deaminase is of importance in ATP regeneration, reduced activity of XO, together with the increased AMP-deaminase activity, may suggest that adenine nucleotides are presumably directed to the ATP regenerating process during dietary L-arginine intake.http://dx.doi.org/10.1100/2012/208239 |
| spellingShingle | G. Kocic J. Nikolic T. Jevtovic-Stoimenov D. Sokolovic H. Kocic T. Cvetkovic D. Pavlovic A. Cencic D. Stojanovic L-Arginine Intake Effect on Adenine Nucleotide Metabolism in Rat Parenchymal and Reproductive Tissues The Scientific World Journal |
| title | L-Arginine Intake Effect on Adenine Nucleotide Metabolism in Rat Parenchymal and Reproductive Tissues |
| title_full | L-Arginine Intake Effect on Adenine Nucleotide Metabolism in Rat Parenchymal and Reproductive Tissues |
| title_fullStr | L-Arginine Intake Effect on Adenine Nucleotide Metabolism in Rat Parenchymal and Reproductive Tissues |
| title_full_unstemmed | L-Arginine Intake Effect on Adenine Nucleotide Metabolism in Rat Parenchymal and Reproductive Tissues |
| title_short | L-Arginine Intake Effect on Adenine Nucleotide Metabolism in Rat Parenchymal and Reproductive Tissues |
| title_sort | l arginine intake effect on adenine nucleotide metabolism in rat parenchymal and reproductive tissues |
| url | http://dx.doi.org/10.1100/2012/208239 |
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