Cell Death Mechanisms at the Maternal-Fetal Interface: Insights into the Role of Granulysin
During mammal pregnancy, a sensitive balance between hormones, cytokines, humoral factors, and local cellular interactions must be established. Cytotoxic cells infiltrating the decidua are heavily equipped with cytolytic molecules, in particular perforin and granulysin. Granulysin is especially abun...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/180272 |
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| author | Danijela Veljkovic Vujaklija Sonja Sucic Tamara Gulic Marin Dominovic Daniel Rukavina |
| author_facet | Danijela Veljkovic Vujaklija Sonja Sucic Tamara Gulic Marin Dominovic Daniel Rukavina |
| author_sort | Danijela Veljkovic Vujaklija |
| collection | DOAJ |
| description | During mammal pregnancy, a sensitive balance between hormones, cytokines, humoral factors, and local cellular interactions must be established. Cytotoxic cells infiltrating the decidua are heavily equipped with cytolytic molecules, in particular perforin and granulysin. Granulysin is especially abundant in NK cells which are able to spontaneously secrete high quantities of granulysin. Besides being a potent bactericidal and tumoricidal molecule, granulysin is also found to be a chemoattractant and a proinflammatory molecule. The precise role(s) of granulysin at the maternal-fetal interface has not been elucidated yet. It is possible that it behaves as a double-edged sword simultaneously acting as an immunomodulatory and a host defense molecule protecting both the mother and the fetus from a wide spectrum of pathogens, and on the other hand, in case of an NK cell activation, acting as an effector molecule causing the apoptosis of semiallograft trophoblast cells and consequently leading to various pregnancy disorders or pregnancy loss. |
| format | Article |
| id | doaj-art-474e438d2e304136846f65e8016e7556 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-474e438d2e304136846f65e8016e75562025-08-20T03:36:45ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/180272180272Cell Death Mechanisms at the Maternal-Fetal Interface: Insights into the Role of GranulysinDanijela Veljkovic Vujaklija0Sonja Sucic1Tamara Gulic2Marin Dominovic3Daniel Rukavina4Department of Physiology and Immunology, Medical Faculty, University of Rijeka, 51000 Rijeka, CroatiaDepartment of Physiology and Immunology, Medical Faculty, University of Rijeka, 51000 Rijeka, CroatiaDepartment of Physiology and Immunology, Medical Faculty, University of Rijeka, 51000 Rijeka, CroatiaDepartment of Physiology and Immunology, Medical Faculty, University of Rijeka, 51000 Rijeka, CroatiaDepartment of Physiology and Immunology, Medical Faculty, University of Rijeka, 51000 Rijeka, CroatiaDuring mammal pregnancy, a sensitive balance between hormones, cytokines, humoral factors, and local cellular interactions must be established. Cytotoxic cells infiltrating the decidua are heavily equipped with cytolytic molecules, in particular perforin and granulysin. Granulysin is especially abundant in NK cells which are able to spontaneously secrete high quantities of granulysin. Besides being a potent bactericidal and tumoricidal molecule, granulysin is also found to be a chemoattractant and a proinflammatory molecule. The precise role(s) of granulysin at the maternal-fetal interface has not been elucidated yet. It is possible that it behaves as a double-edged sword simultaneously acting as an immunomodulatory and a host defense molecule protecting both the mother and the fetus from a wide spectrum of pathogens, and on the other hand, in case of an NK cell activation, acting as an effector molecule causing the apoptosis of semiallograft trophoblast cells and consequently leading to various pregnancy disorders or pregnancy loss.http://dx.doi.org/10.1155/2012/180272 |
| spellingShingle | Danijela Veljkovic Vujaklija Sonja Sucic Tamara Gulic Marin Dominovic Daniel Rukavina Cell Death Mechanisms at the Maternal-Fetal Interface: Insights into the Role of Granulysin Clinical and Developmental Immunology |
| title | Cell Death Mechanisms at the Maternal-Fetal Interface: Insights into the Role of Granulysin |
| title_full | Cell Death Mechanisms at the Maternal-Fetal Interface: Insights into the Role of Granulysin |
| title_fullStr | Cell Death Mechanisms at the Maternal-Fetal Interface: Insights into the Role of Granulysin |
| title_full_unstemmed | Cell Death Mechanisms at the Maternal-Fetal Interface: Insights into the Role of Granulysin |
| title_short | Cell Death Mechanisms at the Maternal-Fetal Interface: Insights into the Role of Granulysin |
| title_sort | cell death mechanisms at the maternal fetal interface insights into the role of granulysin |
| url | http://dx.doi.org/10.1155/2012/180272 |
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