Prognostic value of myocardial flow reserve by PET imaging in patients with suspected coronary artery disease: A systematic review and meta-analysis
Purpose: We performed a systematic review and meta-analysis of published studies evaluating the value of myocardial flow reserve (MFR) assessed by positron emission tomography (PET) imaging in predicting adverse cardiovascular events in patients with suspected coronary artery disease (CAD). Material...
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Elsevier
2025-06-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906725000806 |
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| author | Adriana D’Antonio Roberta Assante Emilia Zampella Valeria Cantoni Roberta Green Valeria Gaudieri Teresa Mannarino Maria Falzarano Federica Volpicelli Paolo Cutillo Francesca Matrisciano Pietro Buongiorno Mariarosaria Panico Carmela Nappi Domenico Cozzolino Mario Petretta Alberto Cuocolo Wanda Acampa |
| author_facet | Adriana D’Antonio Roberta Assante Emilia Zampella Valeria Cantoni Roberta Green Valeria Gaudieri Teresa Mannarino Maria Falzarano Federica Volpicelli Paolo Cutillo Francesca Matrisciano Pietro Buongiorno Mariarosaria Panico Carmela Nappi Domenico Cozzolino Mario Petretta Alberto Cuocolo Wanda Acampa |
| author_sort | Adriana D’Antonio |
| collection | DOAJ |
| description | Purpose: We performed a systematic review and meta-analysis of published studies evaluating the value of myocardial flow reserve (MFR) assessed by positron emission tomography (PET) imaging in predicting adverse cardiovascular events in patients with suspected coronary artery disease (CAD). Material and methods: Studies published until December 2024 were identified by database search. We included studies evaluating MFR by PET imaging with data on adjusted hazard ratio (HR) for the occurrence of adverse cardiovascular events. Results: We identified 8 eligible articles including 12.087 patients with a mean follow-up of 2.98 ± 0.69 years. The pooled HR for the occurrence of events was 2.19 (95 % CI 1.80–2.68) and no heterogeneity was observed. The pooled incidence rate ratio (IRR) was 3.26 (95 % CI 2.43–4.37) and the heterogeneity was 37.7 %. At meta-regression analysis no significant association was found between HR for adverse events and demographic and clinical variables considered. Conclusion: MFR assessed by PET imaging is a valuable noninvasive prognostic indicator in the evaluation of patients with suspected CAD. |
| format | Article |
| id | doaj-art-4740413cc45f48c5bbd366cce60dffde |
| institution | Kabale University |
| issn | 2352-9067 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj-art-4740413cc45f48c5bbd366cce60dffde2025-08-20T03:49:46ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672025-06-015810167710.1016/j.ijcha.2025.101677Prognostic value of myocardial flow reserve by PET imaging in patients with suspected coronary artery disease: A systematic review and meta-analysisAdriana D’Antonio0Roberta Assante1Emilia Zampella2Valeria Cantoni3Roberta Green4Valeria Gaudieri5Teresa Mannarino6Maria Falzarano7Federica Volpicelli8Paolo Cutillo9Francesca Matrisciano10Pietro Buongiorno11Mariarosaria Panico12Carmela Nappi13Domenico Cozzolino14Mario Petretta15Alberto Cuocolo16Wanda Acampa17Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, ItalyInstitute of Biostructure and Bioimaging, National Council of Research, Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, ItalyDepartment of Precision Medicine, University of Campania, Luigi Vanvitelli, Naples, ItalyIRCCS SYNLAB SDN, Diagnostic Imaging, Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy; Corresponding author.Purpose: We performed a systematic review and meta-analysis of published studies evaluating the value of myocardial flow reserve (MFR) assessed by positron emission tomography (PET) imaging in predicting adverse cardiovascular events in patients with suspected coronary artery disease (CAD). Material and methods: Studies published until December 2024 were identified by database search. We included studies evaluating MFR by PET imaging with data on adjusted hazard ratio (HR) for the occurrence of adverse cardiovascular events. Results: We identified 8 eligible articles including 12.087 patients with a mean follow-up of 2.98 ± 0.69 years. The pooled HR for the occurrence of events was 2.19 (95 % CI 1.80–2.68) and no heterogeneity was observed. The pooled incidence rate ratio (IRR) was 3.26 (95 % CI 2.43–4.37) and the heterogeneity was 37.7 %. At meta-regression analysis no significant association was found between HR for adverse events and demographic and clinical variables considered. Conclusion: MFR assessed by PET imaging is a valuable noninvasive prognostic indicator in the evaluation of patients with suspected CAD.http://www.sciencedirect.com/science/article/pii/S2352906725000806PETPrognostic application |
| spellingShingle | Adriana D’Antonio Roberta Assante Emilia Zampella Valeria Cantoni Roberta Green Valeria Gaudieri Teresa Mannarino Maria Falzarano Federica Volpicelli Paolo Cutillo Francesca Matrisciano Pietro Buongiorno Mariarosaria Panico Carmela Nappi Domenico Cozzolino Mario Petretta Alberto Cuocolo Wanda Acampa Prognostic value of myocardial flow reserve by PET imaging in patients with suspected coronary artery disease: A systematic review and meta-analysis International Journal of Cardiology: Heart & Vasculature PET Prognostic application |
| title | Prognostic value of myocardial flow reserve by PET imaging in patients with suspected coronary artery disease: A systematic review and meta-analysis |
| title_full | Prognostic value of myocardial flow reserve by PET imaging in patients with suspected coronary artery disease: A systematic review and meta-analysis |
| title_fullStr | Prognostic value of myocardial flow reserve by PET imaging in patients with suspected coronary artery disease: A systematic review and meta-analysis |
| title_full_unstemmed | Prognostic value of myocardial flow reserve by PET imaging in patients with suspected coronary artery disease: A systematic review and meta-analysis |
| title_short | Prognostic value of myocardial flow reserve by PET imaging in patients with suspected coronary artery disease: A systematic review and meta-analysis |
| title_sort | prognostic value of myocardial flow reserve by pet imaging in patients with suspected coronary artery disease a systematic review and meta analysis |
| topic | PET Prognostic application |
| url | http://www.sciencedirect.com/science/article/pii/S2352906725000806 |
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