Experimental study of systemic hemostatic effects of fibrin monomer in inhibition of platelet aggregation function
Aim. The study objective was to examine fibrin monomer hemostatic effects in post-traumatic parenchymal hemorrhage in the setting of pharmacologically associated platelet aggregation inhibition.Materials and methods. In the in vivo experimental study on male rabbits, the hemostatic effects of fibrin...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2020-04-01
|
| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/2678 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849773481117351936 |
|---|---|
| author | V. M. Vdovin A. P. Momot D. A. Orekhov I. G. Tolstokorov N. A. Lycheva V. O. Shevchenko I. I. Shakhmatov V. O. Krasyukova E. V. Fogt |
| author_facet | V. M. Vdovin A. P. Momot D. A. Orekhov I. G. Tolstokorov N. A. Lycheva V. O. Shevchenko I. I. Shakhmatov V. O. Krasyukova E. V. Fogt |
| author_sort | V. M. Vdovin |
| collection | DOAJ |
| description | Aim. The study objective was to examine fibrin monomer hemostatic effects in post-traumatic parenchymal hemorrhage in the setting of pharmacologically associated platelet aggregation inhibition.Materials and methods. In the in vivo experimental study on male rabbits, the hemostatic effects of fibrin monomer (FM) (0.25 mg/kg) were evaluated in comparison with tranexamic acid (TA) (15 mg/kg) in post-traumatic parenchymal hemorrhage against the background of preliminary inhibition of platelet aggregation function with acetylsalicylic acid (2.0 mg/kg) and clopidogrel (8.0 mg/kg). Volume and rate of blood loss were estimated, as well as the parameters of the hemostatic system.Results. It has been established that FM versus placebo when administered intravenously 1 hour before the injury can prevent severe bleeding associated with taking antiplatelet agents. The volume of blood loss after FM administration decreased in median by 6.0 times, the rate of blood loss – by 5.9 times, and when using TA – by 2.4 (РFM-TA < 0.02) and 4.8 times respectively. The hemostatic effects of TA were realized when the hemostatic balance was shifted towards the increased fibrin formation (an increase in the level of D-dimer in the blood plasma). The use of FM was not accompanied by any significant changes in the blood coagulation system.Conclusion. The fibrin monomer at a dose of 0.25 mg/kg i.v. is capable of preventing severe posttraumatic parenchymal bleeding caused by the combined use of drugs with different antiplatelet action. The phenomenon is not completely clear and needs to be analyzed in further research. The mechanism of hemostatic effects associated with FM is currently being studied. |
| format | Article |
| id | doaj-art-473f8d2e6a324c98a9412a463eea29ab |
| institution | DOAJ |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2020-04-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-473f8d2e6a324c98a9412a463eea29ab2025-08-20T03:02:03ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842020-04-01191364210.20538/1682-0363-2020-1-36-421594Experimental study of systemic hemostatic effects of fibrin monomer in inhibition of platelet aggregation functionV. M. Vdovin0A. P. Momot1D. A. Orekhov2I. G. Tolstokorov3N. A. Lycheva4V. O. Shevchenko5I. I. Shakhmatov6V. O. Krasyukova7E. V. Fogt8Altai State Medical University (ASMU); Research Institute of Physiology and Fundamental MedicineAltai Branch of National Research Center for Hematology; Research Institute of Physiology and Fundamental MedicineAltai Regional Cardiology Health CenterConsulting Diagnostic Center «Dobryi Doktor» Ltd.Research Institute of Physiology and Fundamental MedicineConsulting Diagnostic Center «Dobryi Doktor» Ltd.Altai State Medical University (ASMU); Research Institute of Physiology and Fundamental MedicineAltai State Medical University (ASMU)Altai State Medical University (ASMU)Aim. The study objective was to examine fibrin monomer hemostatic effects in post-traumatic parenchymal hemorrhage in the setting of pharmacologically associated platelet aggregation inhibition.Materials and methods. In the in vivo experimental study on male rabbits, the hemostatic effects of fibrin monomer (FM) (0.25 mg/kg) were evaluated in comparison with tranexamic acid (TA) (15 mg/kg) in post-traumatic parenchymal hemorrhage against the background of preliminary inhibition of platelet aggregation function with acetylsalicylic acid (2.0 mg/kg) and clopidogrel (8.0 mg/kg). Volume and rate of blood loss were estimated, as well as the parameters of the hemostatic system.Results. It has been established that FM versus placebo when administered intravenously 1 hour before the injury can prevent severe bleeding associated with taking antiplatelet agents. The volume of blood loss after FM administration decreased in median by 6.0 times, the rate of blood loss – by 5.9 times, and when using TA – by 2.4 (РFM-TA < 0.02) and 4.8 times respectively. The hemostatic effects of TA were realized when the hemostatic balance was shifted towards the increased fibrin formation (an increase in the level of D-dimer in the blood plasma). The use of FM was not accompanied by any significant changes in the blood coagulation system.Conclusion. The fibrin monomer at a dose of 0.25 mg/kg i.v. is capable of preventing severe posttraumatic parenchymal bleeding caused by the combined use of drugs with different antiplatelet action. The phenomenon is not completely clear and needs to be analyzed in further research. The mechanism of hemostatic effects associated with FM is currently being studied.https://bulletin.ssmu.ru/jour/article/view/2678fibrin monomeracetylsalicylic acidclopidogreltranexamic acidhemostatic effect |
| spellingShingle | V. M. Vdovin A. P. Momot D. A. Orekhov I. G. Tolstokorov N. A. Lycheva V. O. Shevchenko I. I. Shakhmatov V. O. Krasyukova E. V. Fogt Experimental study of systemic hemostatic effects of fibrin monomer in inhibition of platelet aggregation function Бюллетень сибирской медицины fibrin monomer acetylsalicylic acid clopidogrel tranexamic acid hemostatic effect |
| title | Experimental study of systemic hemostatic effects of fibrin monomer in inhibition of platelet aggregation function |
| title_full | Experimental study of systemic hemostatic effects of fibrin monomer in inhibition of platelet aggregation function |
| title_fullStr | Experimental study of systemic hemostatic effects of fibrin monomer in inhibition of platelet aggregation function |
| title_full_unstemmed | Experimental study of systemic hemostatic effects of fibrin monomer in inhibition of platelet aggregation function |
| title_short | Experimental study of systemic hemostatic effects of fibrin monomer in inhibition of platelet aggregation function |
| title_sort | experimental study of systemic hemostatic effects of fibrin monomer in inhibition of platelet aggregation function |
| topic | fibrin monomer acetylsalicylic acid clopidogrel tranexamic acid hemostatic effect |
| url | https://bulletin.ssmu.ru/jour/article/view/2678 |
| work_keys_str_mv | AT vmvdovin experimentalstudyofsystemichemostaticeffectsoffibrinmonomerininhibitionofplateletaggregationfunction AT apmomot experimentalstudyofsystemichemostaticeffectsoffibrinmonomerininhibitionofplateletaggregationfunction AT daorekhov experimentalstudyofsystemichemostaticeffectsoffibrinmonomerininhibitionofplateletaggregationfunction AT igtolstokorov experimentalstudyofsystemichemostaticeffectsoffibrinmonomerininhibitionofplateletaggregationfunction AT nalycheva experimentalstudyofsystemichemostaticeffectsoffibrinmonomerininhibitionofplateletaggregationfunction AT voshevchenko experimentalstudyofsystemichemostaticeffectsoffibrinmonomerininhibitionofplateletaggregationfunction AT iishakhmatov experimentalstudyofsystemichemostaticeffectsoffibrinmonomerininhibitionofplateletaggregationfunction AT vokrasyukova experimentalstudyofsystemichemostaticeffectsoffibrinmonomerininhibitionofplateletaggregationfunction AT evfogt experimentalstudyofsystemichemostaticeffectsoffibrinmonomerininhibitionofplateletaggregationfunction |