Development of a shielding device for radiotherapy of breast cancer-bearing mice
Breast cancer is the fifth most common cause of death worldwide. Currently, one of the standard treatments for breast cancer is radiation therapy (RT). On the other hand, mouse models have been used in pre-clinical studies for breast cancer RT, requiring dedicated shielding to exposure the breast r...
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| Format: | Article |
| Language: | English |
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Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)
2020-06-01
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| Series: | Brazilian Journal of Radiation Sciences |
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| Online Access: | https://bjrs.org.br/revista/index.php/REVISTA/article/view/1164 |
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| author | Camila R. Silva Saulo Toledo Pereira Celia Marina Napolitano Elizabeth Ribeiro Somessari Martha Simões Ribeiro |
| author_facet | Camila R. Silva Saulo Toledo Pereira Celia Marina Napolitano Elizabeth Ribeiro Somessari Martha Simões Ribeiro |
| author_sort | Camila R. Silva |
| collection | DOAJ |
| description | Breast cancer is the fifth most common cause of death worldwide. Currently, one of the standard treatments for breast cancer is radiation therapy (RT). On the other hand, mouse models have been used in pre-clinical studies for breast cancer RT, requiring dedicated shielding to exposure the breast region. In this work, we considered the values of the lead attenuation coefficient and the tenth reducing layer for a 60Co irradiator and developed a lead shielding device for breast cancer-bearing mice to be exposed to localized breast RT. Five-kg of lead were exposed to temperature of 340ºC and inserted into an aluminum mold previously adjusted to the dimensions of the device. After solidification, the device was shaped into a cylinder with dimension of 14 x 15 x 7 cm (height x width x thickness, respectively). A round cut-out for breast exposure of 1 cm in diameter was made at 5 cm from the basis of the device. For shielding device validation, we performed calibrations to establish a dose of 10 Gy in the target. Fifteen CaSO4:Dy thermoluminescent dosimeters were distributed along a 50 mL conical tube to simulate the mouse position inside the shielding. The shielding device was placed at a fixed distance of 10 cm from the target for optimal exposure time. After irradiation, the dosimeters were read on a thermoluminescent reader. According to our results, we were able to develop a body-shielding device that assured the required dose for RT of breast cancer in mice. |
| format | Article |
| id | doaj-art-473ccabd76b84f128ce0adf8d2b37663 |
| institution | Kabale University |
| issn | 2319-0612 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR) |
| record_format | Article |
| series | Brazilian Journal of Radiation Sciences |
| spelling | doaj-art-473ccabd76b84f128ce0adf8d2b376632025-08-20T03:30:25ZengBrazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)Brazilian Journal of Radiation Sciences2319-06122020-06-0181A (Suppl.)10.15392/bjrs.v8i1A.1164903Development of a shielding device for radiotherapy of breast cancer-bearing miceCamila R. Silva0Saulo Toledo Pereira1Celia Marina Napolitano2Elizabeth Ribeiro Somessari3Martha Simões Ribeiro4IPEN-CNEN/SPIPEN-CNEN/SPIPEN-CNEN/SPIPEN-CNEN/SPIPEN-CNEN/SPBreast cancer is the fifth most common cause of death worldwide. Currently, one of the standard treatments for breast cancer is radiation therapy (RT). On the other hand, mouse models have been used in pre-clinical studies for breast cancer RT, requiring dedicated shielding to exposure the breast region. In this work, we considered the values of the lead attenuation coefficient and the tenth reducing layer for a 60Co irradiator and developed a lead shielding device for breast cancer-bearing mice to be exposed to localized breast RT. Five-kg of lead were exposed to temperature of 340ºC and inserted into an aluminum mold previously adjusted to the dimensions of the device. After solidification, the device was shaped into a cylinder with dimension of 14 x 15 x 7 cm (height x width x thickness, respectively). A round cut-out for breast exposure of 1 cm in diameter was made at 5 cm from the basis of the device. For shielding device validation, we performed calibrations to establish a dose of 10 Gy in the target. Fifteen CaSO4:Dy thermoluminescent dosimeters were distributed along a 50 mL conical tube to simulate the mouse position inside the shielding. The shielding device was placed at a fixed distance of 10 cm from the target for optimal exposure time. After irradiation, the dosimeters were read on a thermoluminescent reader. According to our results, we were able to develop a body-shielding device that assured the required dose for RT of breast cancer in mice.https://bjrs.org.br/revista/index.php/REVISTA/article/view/1164ionizing radiationleadthermoluminescent dosimeters |
| spellingShingle | Camila R. Silva Saulo Toledo Pereira Celia Marina Napolitano Elizabeth Ribeiro Somessari Martha Simões Ribeiro Development of a shielding device for radiotherapy of breast cancer-bearing mice Brazilian Journal of Radiation Sciences ionizing radiation lead thermoluminescent dosimeters |
| title | Development of a shielding device for radiotherapy of breast cancer-bearing mice |
| title_full | Development of a shielding device for radiotherapy of breast cancer-bearing mice |
| title_fullStr | Development of a shielding device for radiotherapy of breast cancer-bearing mice |
| title_full_unstemmed | Development of a shielding device for radiotherapy of breast cancer-bearing mice |
| title_short | Development of a shielding device for radiotherapy of breast cancer-bearing mice |
| title_sort | development of a shielding device for radiotherapy of breast cancer bearing mice |
| topic | ionizing radiation lead thermoluminescent dosimeters |
| url | https://bjrs.org.br/revista/index.php/REVISTA/article/view/1164 |
| work_keys_str_mv | AT camilarsilva developmentofashieldingdeviceforradiotherapyofbreastcancerbearingmice AT saulotoledopereira developmentofashieldingdeviceforradiotherapyofbreastcancerbearingmice AT celiamarinanapolitano developmentofashieldingdeviceforradiotherapyofbreastcancerbearingmice AT elizabethribeirosomessari developmentofashieldingdeviceforradiotherapyofbreastcancerbearingmice AT marthasimoesribeiro developmentofashieldingdeviceforradiotherapyofbreastcancerbearingmice |