CDK6 protects epithelial ovarian cancer from platinum‐induced death via FOXO3 regulation

CDK6 protects epithelial ovarian cancer from platinum‐induced death via FOXO3 regulation

Abstract Epithelial ovarian cancer (EOC) is an infrequent but highly lethal disease, almost invariably treated with platinum‐based therapies. Improving the response to platinum represents a great challenge, since it could significantly impact on patient survival. Here, we report that silencing or ph...

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Bibliographic Details
Main Authors: Alessandra Dall'Acqua, Maura Sonego, Ilenia Pellizzari, Ilenia Pellarin, Vincenzo Canzonieri, Sara D'Andrea, Sara Benevol, Roberto Sorio, Giorgio Giorda, Daniela Califano, Marina Bagnoli, Loredana Militello, Delia Mezzanzanica, Gennaro Chiappetta, Joshua Armenia, Barbara Belletti, Monica Schiappacassi, Gustavo Baldassarre
Format: Article
Language:English
Published: Springer Nature 2017-08-01
Series:EMBO Molecular Medicine
Subjects:
ATR
CDK6
FOXO3
ovarian cancer
platinum sensitivity
Online Access:https://doi.org/10.15252/emmm.201607012
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