Evaluation of Right Ventricle Function in Children With Primary Nephrotic Syndrome
We aimed to evaluate right ventricle (RV) function in children with primary nephrotic syndrome (PNS). Methods: RV hemodynamics were evaluated by Doppler echocardiography in 50 children with PNS (aged 2.5–12 years), either at PNS onset (n = 37) or relapse (n = 13), and in 50 normal controls. Heart ra...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2010-06-01
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| Series: | Pediatrics and Neonatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957210600319 |
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| Summary: | We aimed to evaluate right ventricle (RV) function in children with primary nephrotic syndrome (PNS).
Methods: RV hemodynamics were evaluated by Doppler echocardiography in 50 children with PNS (aged 2.5–12 years), either at PNS onset (n = 37) or relapse (n = 13), and in 50 normal controls. Heart rate, stroke volume, cardiac output, RV enddiastolic and end-systolic volume, RV ejection fraction, RV end-diastolic pressure, RV peak systolic and end-systolic pressure were determined from pressure-volume loops. The maximal rates of RV pressure upstroke and fall (dP/d tmax and dP/d tmin, respectively) were calculated. Effective pulmonary arterial elastance was calculated as end-systolic pressure divided by stroke volume. Plasma tumor necrosis factor-α (TNF-α) and insulin-like growth factor 1 (IGF-1) were also measured.
Results: RV end-diastolic pressure was increased by an average of 20% in 39 of the patients with PNS, whereas RV ejection fraction was reduced by an average of 15% compared with controls (p < 0.05 for both). Cardiac output and stroke volume were maintained, indicating compensation at the expense of increased RV end-diastolic and end-systolic volumes and increased RV filling pressure (p < 0.05). Plasma TNF-α was elevated in patients with PNS (326 ± 117 kU/L vs. 75 ± 23 kU/L, p < 0.05); IGF-1 was similar in PNS patients and controls.
Conclusion: Right ventricle function was impaired in children with PNS. The characteristics were unrelated to blood pressure and IGF-1, but may be correlated with TNF-α and disease duration. Further studies are needed to evaluate the etiology and clinical implications of this abnormality. |
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| ISSN: | 1875-9572 |