Gender-Specific Association of Oxidative Stress and Inflammation with Cardiovascular Risk Factors in Arab Population
Background. The impact of gender difference on the association between metabolic stress and cardiovascular disease (CVD) remains unclear. We have investigated, for the first time, the gender effect on the oxidative and inflammatory stress responses and assessed their correlation with classical cardi...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/512603 |
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| _version_ | 1849405140911521792 |
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| author | Abdelkrim Khadir Ali Tiss Sina Kavalakatt Kazem Behbehani Mohammed Dehbi Naser Elkum |
| author_facet | Abdelkrim Khadir Ali Tiss Sina Kavalakatt Kazem Behbehani Mohammed Dehbi Naser Elkum |
| author_sort | Abdelkrim Khadir |
| collection | DOAJ |
| description | Background. The impact of gender difference on the association between metabolic stress and cardiovascular disease (CVD) remains unclear. We have investigated, for the first time, the gender effect on the oxidative and inflammatory stress responses and assessed their correlation with classical cardiometabolites in Arab population. Methods. A total of 378 adult Arab participants (193 females) were enrolled in this cross-sectional study. Plasma levels of CRP, IL-6, IL-8, TNF-α, ROS, TBARs, and PON1 were measured and correlated with anthropometric and cardiometabolite parameters of the study population. Results. Compared to females, males had significantly higher FBG, HbA1c, TG, and blood pressure but lower BMI, TC, and HDL (P < 0.05). After adjustment for BMI and WC, females had higher levels of ROS, TBARS, and CRP (P < 0.001) whereas males had increased levels of IL-8, IL-6, and TNF-α (P < 0.05). Moreover, after adjustment for age, BMI, and gender, the levels of TNF-α, IL-6, and ROS were associated with central obesity but not general obesity. Conclusion. Inflammation and oxidative stress contribution to CVD risk in Arab population linked to gender and this risk is better reflected by central obesity. Arab females might be at risk of CVD complications due to increased oxidative stress. |
| format | Article |
| id | doaj-art-4731eb694d964b569bef542007bc5a95 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4731eb694d964b569bef542007bc5a952025-08-20T03:36:45ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/512603512603Gender-Specific Association of Oxidative Stress and Inflammation with Cardiovascular Risk Factors in Arab PopulationAbdelkrim Khadir0Ali Tiss1Sina Kavalakatt2Kazem Behbehani3Mohammed Dehbi4Naser Elkum5Department of Biomedical Research, Dasman Diabetes Institute, 15462 Kuwait City, KuwaitDepartment of Biomedical Research, Dasman Diabetes Institute, 15462 Kuwait City, KuwaitDepartment of Biomedical Research, Dasman Diabetes Institute, 15462 Kuwait City, KuwaitDepartment of Biomedical Research, Dasman Diabetes Institute, 15462 Kuwait City, KuwaitDiabetes Research Centre, Qatar Biomedical Research Institute, Doha, QatarClinical Epidemiology Division, Sidra Medical and Research Center, Doha, QatarBackground. The impact of gender difference on the association between metabolic stress and cardiovascular disease (CVD) remains unclear. We have investigated, for the first time, the gender effect on the oxidative and inflammatory stress responses and assessed their correlation with classical cardiometabolites in Arab population. Methods. A total of 378 adult Arab participants (193 females) were enrolled in this cross-sectional study. Plasma levels of CRP, IL-6, IL-8, TNF-α, ROS, TBARs, and PON1 were measured and correlated with anthropometric and cardiometabolite parameters of the study population. Results. Compared to females, males had significantly higher FBG, HbA1c, TG, and blood pressure but lower BMI, TC, and HDL (P < 0.05). After adjustment for BMI and WC, females had higher levels of ROS, TBARS, and CRP (P < 0.001) whereas males had increased levels of IL-8, IL-6, and TNF-α (P < 0.05). Moreover, after adjustment for age, BMI, and gender, the levels of TNF-α, IL-6, and ROS were associated with central obesity but not general obesity. Conclusion. Inflammation and oxidative stress contribution to CVD risk in Arab population linked to gender and this risk is better reflected by central obesity. Arab females might be at risk of CVD complications due to increased oxidative stress.http://dx.doi.org/10.1155/2015/512603 |
| spellingShingle | Abdelkrim Khadir Ali Tiss Sina Kavalakatt Kazem Behbehani Mohammed Dehbi Naser Elkum Gender-Specific Association of Oxidative Stress and Inflammation with Cardiovascular Risk Factors in Arab Population Mediators of Inflammation |
| title | Gender-Specific Association of Oxidative Stress and Inflammation with Cardiovascular Risk Factors in Arab Population |
| title_full | Gender-Specific Association of Oxidative Stress and Inflammation with Cardiovascular Risk Factors in Arab Population |
| title_fullStr | Gender-Specific Association of Oxidative Stress and Inflammation with Cardiovascular Risk Factors in Arab Population |
| title_full_unstemmed | Gender-Specific Association of Oxidative Stress and Inflammation with Cardiovascular Risk Factors in Arab Population |
| title_short | Gender-Specific Association of Oxidative Stress and Inflammation with Cardiovascular Risk Factors in Arab Population |
| title_sort | gender specific association of oxidative stress and inflammation with cardiovascular risk factors in arab population |
| url | http://dx.doi.org/10.1155/2015/512603 |
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