Real Time Detection and Association of Helicobacter Pylori in Oral Squamous Cell Carcinoma
Background: Helicobacter pylori is a recognized pathogen associated with gastric carcinoma, but its potential role in oral squamous cell carcinoma (OSCC) remains underinvestigated. Objective: To evaluate the prevalence of H. pylori in OSCC patients and compare it with healthy controls, assessing its...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-04-01
|
| Series: | Journal of Indian Academy of Oral Medicine and Radiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jiaomr.jiaomr_25_25 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849427757879001088 |
|---|---|
| author | Kandasamy Murugan Kesavaram Padmavathy Philips Mathew Nalini Ashwath R C Neil Ananth T Saravanan |
| author_facet | Kandasamy Murugan Kesavaram Padmavathy Philips Mathew Nalini Ashwath R C Neil Ananth T Saravanan |
| author_sort | Kandasamy Murugan |
| collection | DOAJ |
| description | Background:
Helicobacter pylori is a recognized pathogen associated with gastric carcinoma, but its potential role in oral squamous cell carcinoma (OSCC) remains underinvestigated.
Objective:
To evaluate the prevalence of H. pylori in OSCC patients and compare it with healthy controls, assessing its potential etiological role in OSCC.
Methods:
This study included 30 participants, OSCC (n = 15) patients and healthy controls (n = 15). Unstimulated saliva was collected from all the study participants, and DNA was extracted, aliquoted, and stored. H. pylori HPUreA gene was detected in the saliva samples by real-time PCR. Histopathological confirmation of the clinical diagnosis of OSCC was performed for the patient group. Statistical analysis was performed to compare the prevalence of H. pylori between the groups and the associations with clinical variables, including lifestyle factors such as smoking and betel nut chewing.
Results:
Statistically significant difference (P < 0.05) was observed in the prevalence of H. pylori between OSCC patients (73.33%) and the healthy controls (26.67%) who tested positive. Nevertheless, no difference in the mean CT value for the positive samples in the control group Vs OSCC group (36.6 ± 1.26 Vs 37.19 ± 1.31) was not statistically significant (P > 0.05).
Conclusion:
The findings suggest a strong association between H. pylori and OSCC, highlighting the potential role of the bacterium in oral carcinogenesis and warranting further research to understand the underlying mechanisms. |
| format | Article |
| id | doaj-art-472f0e2fa5ee436aa51e145be2d7e23b |
| institution | Kabale University |
| issn | 0972-1363 0975-1572 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Academy of Oral Medicine and Radiology |
| spelling | doaj-art-472f0e2fa5ee436aa51e145be2d7e23b2025-08-20T03:28:55ZengWolters Kluwer Medknow PublicationsJournal of Indian Academy of Oral Medicine and Radiology0972-13630975-15722025-04-0137217618010.4103/jiaomr.jiaomr_25_25Real Time Detection and Association of Helicobacter Pylori in Oral Squamous Cell CarcinomaKandasamy MuruganKesavaram PadmavathyPhilips MathewNalini AshwathR C Neil AnanthT SaravananBackground: Helicobacter pylori is a recognized pathogen associated with gastric carcinoma, but its potential role in oral squamous cell carcinoma (OSCC) remains underinvestigated. Objective: To evaluate the prevalence of H. pylori in OSCC patients and compare it with healthy controls, assessing its potential etiological role in OSCC. Methods: This study included 30 participants, OSCC (n = 15) patients and healthy controls (n = 15). Unstimulated saliva was collected from all the study participants, and DNA was extracted, aliquoted, and stored. H. pylori HPUreA gene was detected in the saliva samples by real-time PCR. Histopathological confirmation of the clinical diagnosis of OSCC was performed for the patient group. Statistical analysis was performed to compare the prevalence of H. pylori between the groups and the associations with clinical variables, including lifestyle factors such as smoking and betel nut chewing. Results: Statistically significant difference (P < 0.05) was observed in the prevalence of H. pylori between OSCC patients (73.33%) and the healthy controls (26.67%) who tested positive. Nevertheless, no difference in the mean CT value for the positive samples in the control group Vs OSCC group (36.6 ± 1.26 Vs 37.19 ± 1.31) was not statistically significant (P > 0.05). Conclusion: The findings suggest a strong association between H. pylori and OSCC, highlighting the potential role of the bacterium in oral carcinogenesis and warranting further research to understand the underlying mechanisms.https://journals.lww.com/10.4103/jiaomr.jiaomr_25_25biomarkerstumorhelicobacter pylorioral squamous cell carcinomareal-time polymerase chain reactionsquamous cell carcinoma of head and neckurease |
| spellingShingle | Kandasamy Murugan Kesavaram Padmavathy Philips Mathew Nalini Ashwath R C Neil Ananth T Saravanan Real Time Detection and Association of Helicobacter Pylori in Oral Squamous Cell Carcinoma Journal of Indian Academy of Oral Medicine and Radiology biomarkers tumor helicobacter pylori oral squamous cell carcinoma real-time polymerase chain reaction squamous cell carcinoma of head and neck urease |
| title | Real Time Detection and Association of Helicobacter Pylori in Oral Squamous Cell Carcinoma |
| title_full | Real Time Detection and Association of Helicobacter Pylori in Oral Squamous Cell Carcinoma |
| title_fullStr | Real Time Detection and Association of Helicobacter Pylori in Oral Squamous Cell Carcinoma |
| title_full_unstemmed | Real Time Detection and Association of Helicobacter Pylori in Oral Squamous Cell Carcinoma |
| title_short | Real Time Detection and Association of Helicobacter Pylori in Oral Squamous Cell Carcinoma |
| title_sort | real time detection and association of helicobacter pylori in oral squamous cell carcinoma |
| topic | biomarkers tumor helicobacter pylori oral squamous cell carcinoma real-time polymerase chain reaction squamous cell carcinoma of head and neck urease |
| url | https://journals.lww.com/10.4103/jiaomr.jiaomr_25_25 |
| work_keys_str_mv | AT kandasamymurugan realtimedetectionandassociationofhelicobacterpyloriinoralsquamouscellcarcinoma AT kesavarampadmavathy realtimedetectionandassociationofhelicobacterpyloriinoralsquamouscellcarcinoma AT philipsmathew realtimedetectionandassociationofhelicobacterpyloriinoralsquamouscellcarcinoma AT naliniashwath realtimedetectionandassociationofhelicobacterpyloriinoralsquamouscellcarcinoma AT rcneilananth realtimedetectionandassociationofhelicobacterpyloriinoralsquamouscellcarcinoma AT tsaravanan realtimedetectionandassociationofhelicobacterpyloriinoralsquamouscellcarcinoma |