Correlation between admission blood glucose, fibrinogen, and slow blood flow during primary PCI for acute ST segment elevation myocardial infarction
BackgroudCoronary slow flow (CSF) is a common phenomenon of coronary microcirculation dysfunction, and is closely related to elevated blood glucose and fibrinogen (FIB) levels. However, whether immediate blood glucose and FIB levels affect coronary blood flow during primary percutaneous coronary int...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1478743/full |
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| author | Wu Zufei Wu Zufei Su Wentao Su Wentao Shi Chen Bai Da Xu Bai Da Xu Gang Jun Zong Gang Jun Zong Gang-Yong Wu Gang-Yong Wu |
| author_facet | Wu Zufei Wu Zufei Su Wentao Su Wentao Shi Chen Bai Da Xu Bai Da Xu Gang Jun Zong Gang Jun Zong Gang-Yong Wu Gang-Yong Wu |
| author_sort | Wu Zufei |
| collection | DOAJ |
| description | BackgroudCoronary slow flow (CSF) is a common phenomenon of coronary microcirculation dysfunction, and is closely related to elevated blood glucose and fibrinogen (FIB) levels. However, whether immediate blood glucose and FIB levels affect coronary blood flow during primary percutaneous coronary intervention (PCI) remains unclear.ObjectiveTo explore the correlation between admission blood glucose (ABG), fibrinogen (FIB) and slow blood flow during primary PCI for acute ST segment elevation myocardial infarction (STEMI).MethodsA total of 497 patients who underwent coronary angiography in the cardiology department of the 904th Hospital of the Joint Logistics Support Force from December 2018 to December 2022 due to STEMI were selected consecutively, and then were divided into two groups based on whether slow blood flow occurred during primary PCI: slow blood flow group (n = 117) and control group (n = 380). Detecting the ABG, FIB and other indicators of patients in each group, and using logistic regression analysis and receiver operating characteristic (ROC) curve to analyze independent risk factors for slow blood flow during primary PCI, and further evaluating the prognosis of patients.ResultsThe levels of ABG and FIB in patients with slow blood flow were significantly higher than those in the control group (P < 0.05). The results of multivariate logistic regression analysis suggested that FIB and ABG were independent risk factors for slow blood flow during primary PCI (both P < 0.05). ROC curve analysis showed that ABG, FIB, and their combination all had predictive value for slow blood flow during primary PCI (all P < 0.05), and the area under the curve (AUC) of the combined indicator was higher than that of any single indicator, with statistical significance (P < 0.05). KM curve analysis suggested that the prognosis of patients in slow blood flow group were poor.ConclusionBoth elevated ABG and FIB could predict slow blood flow during primary PCI, and the diagnostic value of the combined indicator was superior to that of any single indicator, which could be used for the evaluation of slow blood flow during primary PCI, so as to evaluate the prognosis of patients with STEMI. |
| format | Article |
| id | doaj-art-472d45dc270e463984d8887c9417ff2f |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-472d45dc270e463984d8887c9417ff2f2025-08-20T02:38:30ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-12-011110.3389/fcvm.2024.14787431478743Correlation between admission blood glucose, fibrinogen, and slow blood flow during primary PCI for acute ST segment elevation myocardial infarctionWu Zufei0Wu Zufei1Su Wentao2Su Wentao3Shi Chen4Bai Da Xu5Bai Da Xu6Gang Jun Zong7Gang Jun Zong8Gang-Yong Wu9Gang-Yong Wu10Department of Cardiology, The 904th Hospital of the PLA Joint Logistics Support Force, Wuxi, Jiangsu, ChinaDepartment of Cardiology, Xuancheng People’s Hospital, Xuanchen, Anhui, ChinaDepartment of Cardiology, The 904th Hospital of the PLA Joint Logistics Support Force, Wuxi, Jiangsu, ChinaDepartment of Cardiology, Wuxi Clinical College of Anhui Medical University, Wuxi, Jiangsu, ChinaDepartment of Cardiology, Wuxi No.5 People’s Hospital, Wuxi, Jiangsu, ChinaDepartment of Cardiology, The 904th Hospital of the PLA Joint Logistics Support Force, Wuxi, Jiangsu, ChinaDepartment of Cardiology, Wuxi Clinical College of Anhui Medical University, Wuxi, Jiangsu, ChinaDepartment of Cardiology, The 904th Hospital of the PLA Joint Logistics Support Force, Wuxi, Jiangsu, ChinaDepartment of Cardiology, Wuxi Clinical College of Anhui Medical University, Wuxi, Jiangsu, ChinaDepartment of Cardiology, The 904th Hospital of the PLA Joint Logistics Support Force, Wuxi, Jiangsu, ChinaDepartment of Cardiology, Wuxi Clinical College of Anhui Medical University, Wuxi, Jiangsu, ChinaBackgroudCoronary slow flow (CSF) is a common phenomenon of coronary microcirculation dysfunction, and is closely related to elevated blood glucose and fibrinogen (FIB) levels. However, whether immediate blood glucose and FIB levels affect coronary blood flow during primary percutaneous coronary intervention (PCI) remains unclear.ObjectiveTo explore the correlation between admission blood glucose (ABG), fibrinogen (FIB) and slow blood flow during primary PCI for acute ST segment elevation myocardial infarction (STEMI).MethodsA total of 497 patients who underwent coronary angiography in the cardiology department of the 904th Hospital of the Joint Logistics Support Force from December 2018 to December 2022 due to STEMI were selected consecutively, and then were divided into two groups based on whether slow blood flow occurred during primary PCI: slow blood flow group (n = 117) and control group (n = 380). Detecting the ABG, FIB and other indicators of patients in each group, and using logistic regression analysis and receiver operating characteristic (ROC) curve to analyze independent risk factors for slow blood flow during primary PCI, and further evaluating the prognosis of patients.ResultsThe levels of ABG and FIB in patients with slow blood flow were significantly higher than those in the control group (P < 0.05). The results of multivariate logistic regression analysis suggested that FIB and ABG were independent risk factors for slow blood flow during primary PCI (both P < 0.05). ROC curve analysis showed that ABG, FIB, and their combination all had predictive value for slow blood flow during primary PCI (all P < 0.05), and the area under the curve (AUC) of the combined indicator was higher than that of any single indicator, with statistical significance (P < 0.05). KM curve analysis suggested that the prognosis of patients in slow blood flow group were poor.ConclusionBoth elevated ABG and FIB could predict slow blood flow during primary PCI, and the diagnostic value of the combined indicator was superior to that of any single indicator, which could be used for the evaluation of slow blood flow during primary PCI, so as to evaluate the prognosis of patients with STEMI.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1478743/fulladmission blood glucosefibrinogenacute ST segment elevation myocardial infarctionpercutaneous coronary interventionslow blood flow |
| spellingShingle | Wu Zufei Wu Zufei Su Wentao Su Wentao Shi Chen Bai Da Xu Bai Da Xu Gang Jun Zong Gang Jun Zong Gang-Yong Wu Gang-Yong Wu Correlation between admission blood glucose, fibrinogen, and slow blood flow during primary PCI for acute ST segment elevation myocardial infarction Frontiers in Cardiovascular Medicine admission blood glucose fibrinogen acute ST segment elevation myocardial infarction percutaneous coronary intervention slow blood flow |
| title | Correlation between admission blood glucose, fibrinogen, and slow blood flow during primary PCI for acute ST segment elevation myocardial infarction |
| title_full | Correlation between admission blood glucose, fibrinogen, and slow blood flow during primary PCI for acute ST segment elevation myocardial infarction |
| title_fullStr | Correlation between admission blood glucose, fibrinogen, and slow blood flow during primary PCI for acute ST segment elevation myocardial infarction |
| title_full_unstemmed | Correlation between admission blood glucose, fibrinogen, and slow blood flow during primary PCI for acute ST segment elevation myocardial infarction |
| title_short | Correlation between admission blood glucose, fibrinogen, and slow blood flow during primary PCI for acute ST segment elevation myocardial infarction |
| title_sort | correlation between admission blood glucose fibrinogen and slow blood flow during primary pci for acute st segment elevation myocardial infarction |
| topic | admission blood glucose fibrinogen acute ST segment elevation myocardial infarction percutaneous coronary intervention slow blood flow |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1478743/full |
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