Datopotamab deruxtecan induces hallmarks of immunogenic cell death

Datopotamab deruxtecan induces hallmarks of immunogenic cell death

Antibody-drug conjugates (ADCs) offer a strategy for targeted delivery of cytotoxic agents to cancer cells. In this study, we investigated the mechanism of action of datopotamab deruxtecan, an ADC composed of a monoclonal antibody targeting tumor-associated calcium signal transducer 2 (TACSTD2, also...

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Bibliographic Details
Main Authors: Sabrina Forveille, Marion Leduc, Allan Sauvat, Guido Kroemer, Oliver Kepp
Format: Article
Language:English
Published: Shared Science Publishers OG 2025-08-01
Series:Cell Stress
Subjects:
anticancer immunotherapy
antibody drug conjugate
bystander effect
Online Access:http://microbialcell.com/researcharticles/2025a-forveille-cell-stress
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