New insights for the development of efficient DNA vaccines
Abstract Despite the great potential of DNA vaccines for a broad range of applications, ranging from prevention of infections, over treatment of autoimmune and allergic diseases to cancer immunotherapies, the implementation of such therapies for clinical treatment is far behind the expectations up t...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | Microbial Biotechnology |
| Online Access: | https://doi.org/10.1111/1751-7915.70053 |
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| _version_ | 1850224746602430464 |
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| author | Simone Berger Yanira Zeyn Ernst Wagner Matthias Bros |
| author_facet | Simone Berger Yanira Zeyn Ernst Wagner Matthias Bros |
| author_sort | Simone Berger |
| collection | DOAJ |
| description | Abstract Despite the great potential of DNA vaccines for a broad range of applications, ranging from prevention of infections, over treatment of autoimmune and allergic diseases to cancer immunotherapies, the implementation of such therapies for clinical treatment is far behind the expectations up to now. The main reason is the poor immunogenicity of DNA vaccines in humans. Consequently, the improvement of the performance of DNA vaccines in vivo is required. This mini‐review provides an overview of the current state of DNA vaccines and the various strategies to enhance the immunogenic potential of DNA vaccines, including (i) the optimization of the DNA construct itself regarding size, nuclear transfer and transcriptional regulation; (ii) the use of appropriate adjuvants; and (iii) improved delivery, for example, by careful choice of the administration route, physical methods such as electroporation and nanomaterials that may allow cell type‐specific targeting. Moreover, combining nanoformulated DNA vaccines with other immunotherapies and prime‐boost strategies may help to enhance success of treatment. |
| format | Article |
| id | doaj-art-472978ecc1cc405ebf1ce4ccd8f03243 |
| institution | OA Journals |
| issn | 1751-7915 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Microbial Biotechnology |
| spelling | doaj-art-472978ecc1cc405ebf1ce4ccd8f032432025-08-20T02:05:32ZengWileyMicrobial Biotechnology1751-79152024-11-011711n/an/a10.1111/1751-7915.70053New insights for the development of efficient DNA vaccinesSimone Berger0Yanira Zeyn1Ernst Wagner2Matthias Bros3Pharmaceutical Biotechnology, Department of Pharmacy, Center for NanoScience Ludwig‐Maximilians‐Universität (LMU) Munich Munich GermanyDepartment of Dermatology University Medical Center of the Johannes Gutenberg University (JGU) Mainz Mainz GermanyPharmaceutical Biotechnology, Department of Pharmacy, Center for NanoScience Ludwig‐Maximilians‐Universität (LMU) Munich Munich GermanyDepartment of Dermatology University Medical Center of the Johannes Gutenberg University (JGU) Mainz Mainz GermanyAbstract Despite the great potential of DNA vaccines for a broad range of applications, ranging from prevention of infections, over treatment of autoimmune and allergic diseases to cancer immunotherapies, the implementation of such therapies for clinical treatment is far behind the expectations up to now. The main reason is the poor immunogenicity of DNA vaccines in humans. Consequently, the improvement of the performance of DNA vaccines in vivo is required. This mini‐review provides an overview of the current state of DNA vaccines and the various strategies to enhance the immunogenic potential of DNA vaccines, including (i) the optimization of the DNA construct itself regarding size, nuclear transfer and transcriptional regulation; (ii) the use of appropriate adjuvants; and (iii) improved delivery, for example, by careful choice of the administration route, physical methods such as electroporation and nanomaterials that may allow cell type‐specific targeting. Moreover, combining nanoformulated DNA vaccines with other immunotherapies and prime‐boost strategies may help to enhance success of treatment.https://doi.org/10.1111/1751-7915.70053 |
| spellingShingle | Simone Berger Yanira Zeyn Ernst Wagner Matthias Bros New insights for the development of efficient DNA vaccines Microbial Biotechnology |
| title | New insights for the development of efficient DNA vaccines |
| title_full | New insights for the development of efficient DNA vaccines |
| title_fullStr | New insights for the development of efficient DNA vaccines |
| title_full_unstemmed | New insights for the development of efficient DNA vaccines |
| title_short | New insights for the development of efficient DNA vaccines |
| title_sort | new insights for the development of efficient dna vaccines |
| url | https://doi.org/10.1111/1751-7915.70053 |
| work_keys_str_mv | AT simoneberger newinsightsforthedevelopmentofefficientdnavaccines AT yanirazeyn newinsightsforthedevelopmentofefficientdnavaccines AT ernstwagner newinsightsforthedevelopmentofefficientdnavaccines AT matthiasbros newinsightsforthedevelopmentofefficientdnavaccines |