Estimated glucose disposal rate is correlated with increased depression: a population-based study
Abstract Background Recent studies have identified a correlation between insulin resistance (IR) and depression. This study aims to explore the correlation between estimated glucose disposal rate (eGDR), a practical and noninvasive measure for assessing IR, and depression in the general population....
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BMC
2024-11-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-024-06257-2 |
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| _version_ | 1846164966457999360 |
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| author | Yuanyuan Chen Hao Lin Jing Xu Xinhe Zhou |
| author_facet | Yuanyuan Chen Hao Lin Jing Xu Xinhe Zhou |
| author_sort | Yuanyuan Chen |
| collection | DOAJ |
| description | Abstract Background Recent studies have identified a correlation between insulin resistance (IR) and depression. This study aims to explore the correlation between estimated glucose disposal rate (eGDR), a practical and noninvasive measure for assessing IR, and depression in the general population. Methods In this population-based cross-sectional study, data from 28,444 adults aged 18 years old or older in the NHANES during the period from 1999 to 2018 were analyzed. The correlation between eGDR and depression was examined through multivariate logistic regression analyses, subgroup analyses, restricted cubic spline, and interaction tests. Furthermore, a mediation analysis was conducted to elucidate the role of the atherogenic index of plasma (AIP) in mediating the effect of eGDR on depression. Results Multivariate logistic regression analysis and restricted cubic splines analysis indicated that eGDR can exhibit a linearly correlation with depression (OR = 0.913; 95% CI: 0.875, 0.953). Subjects in eGDR6-8 and eGDR > 8 groups had a decrease risk of depression as 25.4% and 41.5% than those in the eGDR < 4 group. This negative correlation was more pronounced in those with obesity. Mediation analysis indicated that AIP mediated 9.6% of the correlation between eGDR and depression. Conclusions eGDR was linear negatively correlated with depression, with AIP playing a mediating role. This study provides a novel perspective on the mechanism connecting IR to depression. Managing IR and monitoring AIP may contribute to alleviating depression. |
| format | Article |
| id | doaj-art-471dce812edb45049294679830a472c5 |
| institution | Kabale University |
| issn | 1471-244X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj-art-471dce812edb45049294679830a472c52024-11-17T12:40:18ZengBMCBMC Psychiatry1471-244X2024-11-0124111110.1186/s12888-024-06257-2Estimated glucose disposal rate is correlated with increased depression: a population-based studyYuanyuan Chen0Hao Lin1Jing Xu2Xinhe Zhou3Department of Endocrinology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Gastroenterology, Pingyang Hospital of Wenzhou Medical UniversityDepartment of Endocrinology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Endocrinology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityAbstract Background Recent studies have identified a correlation between insulin resistance (IR) and depression. This study aims to explore the correlation between estimated glucose disposal rate (eGDR), a practical and noninvasive measure for assessing IR, and depression in the general population. Methods In this population-based cross-sectional study, data from 28,444 adults aged 18 years old or older in the NHANES during the period from 1999 to 2018 were analyzed. The correlation between eGDR and depression was examined through multivariate logistic regression analyses, subgroup analyses, restricted cubic spline, and interaction tests. Furthermore, a mediation analysis was conducted to elucidate the role of the atherogenic index of plasma (AIP) in mediating the effect of eGDR on depression. Results Multivariate logistic regression analysis and restricted cubic splines analysis indicated that eGDR can exhibit a linearly correlation with depression (OR = 0.913; 95% CI: 0.875, 0.953). Subjects in eGDR6-8 and eGDR > 8 groups had a decrease risk of depression as 25.4% and 41.5% than those in the eGDR < 4 group. This negative correlation was more pronounced in those with obesity. Mediation analysis indicated that AIP mediated 9.6% of the correlation between eGDR and depression. Conclusions eGDR was linear negatively correlated with depression, with AIP playing a mediating role. This study provides a novel perspective on the mechanism connecting IR to depression. Managing IR and monitoring AIP may contribute to alleviating depression.https://doi.org/10.1186/s12888-024-06257-2Estimated glucose disposal rateDepressionInsulin resistanceWaist circumference |
| spellingShingle | Yuanyuan Chen Hao Lin Jing Xu Xinhe Zhou Estimated glucose disposal rate is correlated with increased depression: a population-based study BMC Psychiatry Estimated glucose disposal rate Depression Insulin resistance Waist circumference |
| title | Estimated glucose disposal rate is correlated with increased depression: a population-based study |
| title_full | Estimated glucose disposal rate is correlated with increased depression: a population-based study |
| title_fullStr | Estimated glucose disposal rate is correlated with increased depression: a population-based study |
| title_full_unstemmed | Estimated glucose disposal rate is correlated with increased depression: a population-based study |
| title_short | Estimated glucose disposal rate is correlated with increased depression: a population-based study |
| title_sort | estimated glucose disposal rate is correlated with increased depression a population based study |
| topic | Estimated glucose disposal rate Depression Insulin resistance Waist circumference |
| url | https://doi.org/10.1186/s12888-024-06257-2 |
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