Cerebral contusions - Pathomechanism, predictive factors for progression and historical and current management
Introduction: Cerebral contusions (CCs) are common traumatic brain injuries known for their propensity to progress. Understanding their mechanical pathogenesis and predictive factors for progression is crucial for optimal management. Research question: To provide an overview of current knowledge on...
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Elsevier
2024-01-01
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| Series: | Brain and Spine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S277252942400585X |
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| author | Unni Jirlow Iftakher Hossain Otto Korhonen Bart Depreitere Elham Rostami |
| author_facet | Unni Jirlow Iftakher Hossain Otto Korhonen Bart Depreitere Elham Rostami |
| author_sort | Unni Jirlow |
| collection | DOAJ |
| description | Introduction: Cerebral contusions (CCs) are common traumatic brain injuries known for their propensity to progress. Understanding their mechanical pathogenesis and predictive factors for progression is crucial for optimal management. Research question: To provide an overview of current knowledge on CCs, including pathomechanisms, predictive factors of contusion progression, and management strategies. Material and methods: A literature search was conducted using PubMed, Scopus and ISI web of knowledge focused on articles in English with the words “cerebral contusion” together with the words “traumatic brain injury”, “pathomechanism”, “progression of contusion”, “predictive factors” and “management” alone or in combination. Results: The management of CCs has evolved alongside the advances in neurointensive care, yet there is no consensus. Evidence on the effectiveness of early surgery, importantly, for the group which has the potential to expand, is limited. Some predictive factors for contusion progression have been identified, including age, injury mechanism, coagulopathy and initial contusion volume which could help to guide decision-making. Discussion and conclusion: While various theories exist on pathomechanisms and several predictive factors for progression have been proposed, consensus on optimal management remains elusive. Individualized care guided by the predictive factors is essential. Challenges posed by antithrombotic medications highlight the need for early intervention strategies.Decompressive craniectomy could serve as a potential tool in severe traumatic brain injury management including contusions. Conducting large cohort studies to refine predictive models and harmonizing management approaches would help to improve outcomes of patients with CCs. |
| format | Article |
| id | doaj-art-471cf6b877c348f59255aa8477e00b17 |
| institution | OA Journals |
| issn | 2772-5294 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain and Spine |
| spelling | doaj-art-471cf6b877c348f59255aa8477e00b172025-08-20T02:37:53ZengElsevierBrain and Spine2772-52942024-01-01410332910.1016/j.bas.2024.103329Cerebral contusions - Pathomechanism, predictive factors for progression and historical and current managementUnni Jirlow0Iftakher Hossain1Otto Korhonen2Bart Depreitere3Elham Rostami4Department of Medical sciences, Section of Neurosurgery, Uppsala University, Uppsala, SwedenNeurocentre, Department of Neurosurgery, Turku University Hospital, Turku, Finland; Department of Clinical Neurosciences, Neurosurgery Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United KingdomNeurocentre, Department of Neurosurgery, Turku University Hospital, Turku, FinlandDepartment of Neurosurgery, University Hospitals Leuven, Leuven, BelgiumDepartment of Medical sciences, Section of Neurosurgery, Uppsala University, Uppsala, Sweden; Corresponding author. Sjukhusvägen 85, 751 85, Uppsala, Sweden.Introduction: Cerebral contusions (CCs) are common traumatic brain injuries known for their propensity to progress. Understanding their mechanical pathogenesis and predictive factors for progression is crucial for optimal management. Research question: To provide an overview of current knowledge on CCs, including pathomechanisms, predictive factors of contusion progression, and management strategies. Material and methods: A literature search was conducted using PubMed, Scopus and ISI web of knowledge focused on articles in English with the words “cerebral contusion” together with the words “traumatic brain injury”, “pathomechanism”, “progression of contusion”, “predictive factors” and “management” alone or in combination. Results: The management of CCs has evolved alongside the advances in neurointensive care, yet there is no consensus. Evidence on the effectiveness of early surgery, importantly, for the group which has the potential to expand, is limited. Some predictive factors for contusion progression have been identified, including age, injury mechanism, coagulopathy and initial contusion volume which could help to guide decision-making. Discussion and conclusion: While various theories exist on pathomechanisms and several predictive factors for progression have been proposed, consensus on optimal management remains elusive. Individualized care guided by the predictive factors is essential. Challenges posed by antithrombotic medications highlight the need for early intervention strategies.Decompressive craniectomy could serve as a potential tool in severe traumatic brain injury management including contusions. Conducting large cohort studies to refine predictive models and harmonizing management approaches would help to improve outcomes of patients with CCs.http://www.sciencedirect.com/science/article/pii/S277252942400585XCerebral contusionTraumatic brain injuryPathomechanismProgression of cerebral contusionPredictive factorsManagement. decompressive craniectomy |
| spellingShingle | Unni Jirlow Iftakher Hossain Otto Korhonen Bart Depreitere Elham Rostami Cerebral contusions - Pathomechanism, predictive factors for progression and historical and current management Brain and Spine Cerebral contusion Traumatic brain injury Pathomechanism Progression of cerebral contusion Predictive factors Management. decompressive craniectomy |
| title | Cerebral contusions - Pathomechanism, predictive factors for progression and historical and current management |
| title_full | Cerebral contusions - Pathomechanism, predictive factors for progression and historical and current management |
| title_fullStr | Cerebral contusions - Pathomechanism, predictive factors for progression and historical and current management |
| title_full_unstemmed | Cerebral contusions - Pathomechanism, predictive factors for progression and historical and current management |
| title_short | Cerebral contusions - Pathomechanism, predictive factors for progression and historical and current management |
| title_sort | cerebral contusions pathomechanism predictive factors for progression and historical and current management |
| topic | Cerebral contusion Traumatic brain injury Pathomechanism Progression of cerebral contusion Predictive factors Management. decompressive craniectomy |
| url | http://www.sciencedirect.com/science/article/pii/S277252942400585X |
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