Calculated inflammatory markers derived from complete blood count results, along with routine laboratory and clinical data, predict treatment failure of acute peritonitis in chronic peritoneal dialysis patients
Background & Aims Complete blood count (CBC)-derived inflammatory markers are predictive biomarkers for the prognosis of many diseases. However, there was no study on patients with peritoneal dialysis-associated peritonitis (PDAP). We aimed to investigate the value of these markers in predicting...
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2179856 |
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| author | Dan Zhou Huibin Yang Li Zeng Wei Yang Fujia Guo Wenting Cui Cong Chen Jiayao Zhao Shuran Wu Ning Yang Hongli Lin Anchun Yin Longkai Li |
| author_facet | Dan Zhou Huibin Yang Li Zeng Wei Yang Fujia Guo Wenting Cui Cong Chen Jiayao Zhao Shuran Wu Ning Yang Hongli Lin Anchun Yin Longkai Li |
| author_sort | Dan Zhou |
| collection | DOAJ |
| description | Background & Aims Complete blood count (CBC)-derived inflammatory markers are predictive biomarkers for the prognosis of many diseases. However, there was no study on patients with peritoneal dialysis-associated peritonitis (PDAP). We aimed to investigate the value of these markers in predicting treatment failure of acute peritonitis in chronic PD patients.Methods The records of 138 peritonitis episodes were reviewed and divided into treatment success or failure groups in a single center for 10 years. CBC-derived markers and other routine data were recorded before peritonitis treatment was initiated. Univariate and multivariate regression analyses and the receiver operating characteristic (ROC) curve about the predictors of treatment outcomes were performed.Results Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and derived NLR were significantly higher in the failure group. Univariate logistic regression results showed that NLR and PLR were risk factors of treatment outcomes. The backward stepwise multivariate logistic regression results demonstrated that NLR [adjusted odds ratio (aOR), 1.376; 95% confidence intervals (CI), 1.105–1.713; p = .004], PLR (aOR, 1.010; 95%CI, 1.004–1.017; p = .002) were risk factors, but hemoglobin-to-lymphocyte ratio (HLR) (aOR, 0.977; 95%CI, 0.963–0.991; p = .001), and SII (aOR, 0.999; 95%CI, 0.998–1.000; p = .040) were protective factors. A combination of age, PD vintage, Gram-positive peritonitis, staphylococcus aureus, culture-negative, NLR, PLR, HLR, and SII would improve prognostic performance. The area under this ROC curve was 0.85, higher than other factors.Conclusions NLR, PLR, HLR, and SII were associated with PDAP outcomes. Age, PD vintage, NLR, and PLR were significant risk factors in PDAP patients. |
| format | Article |
| id | doaj-art-47194751dcdb48cab7aea1242e4347f2 |
| institution | OA Journals |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-47194751dcdb48cab7aea1242e4347f22025-08-20T02:28:50ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2023.2179856Calculated inflammatory markers derived from complete blood count results, along with routine laboratory and clinical data, predict treatment failure of acute peritonitis in chronic peritoneal dialysis patientsDan Zhou0Huibin Yang1Li Zeng2Wei Yang3Fujia Guo4Wenting Cui5Cong Chen6Jiayao Zhao7Shuran Wu8Ning Yang9Hongli Lin10Anchun Yin11Longkai Li12Department of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaFirst Affiliated Hospital, Dalian Medical University, Dalian, ChinaFirst Affiliated Hospital, Dalian Medical University, Dalian, ChinaDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaFirst Affiliated Hospital, Dalian Medical University, Dalian, ChinaDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaFirst Affiliated Hospital, Dalian Medical University, Dalian, ChinaFirst Affiliated Hospital, Dalian Medical University, Dalian, ChinaDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaCollege of Integrative Medicine, Dalian Medical University, Dalian, ChinaDepartment of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaBackground & Aims Complete blood count (CBC)-derived inflammatory markers are predictive biomarkers for the prognosis of many diseases. However, there was no study on patients with peritoneal dialysis-associated peritonitis (PDAP). We aimed to investigate the value of these markers in predicting treatment failure of acute peritonitis in chronic PD patients.Methods The records of 138 peritonitis episodes were reviewed and divided into treatment success or failure groups in a single center for 10 years. CBC-derived markers and other routine data were recorded before peritonitis treatment was initiated. Univariate and multivariate regression analyses and the receiver operating characteristic (ROC) curve about the predictors of treatment outcomes were performed.Results Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and derived NLR were significantly higher in the failure group. Univariate logistic regression results showed that NLR and PLR were risk factors of treatment outcomes. The backward stepwise multivariate logistic regression results demonstrated that NLR [adjusted odds ratio (aOR), 1.376; 95% confidence intervals (CI), 1.105–1.713; p = .004], PLR (aOR, 1.010; 95%CI, 1.004–1.017; p = .002) were risk factors, but hemoglobin-to-lymphocyte ratio (HLR) (aOR, 0.977; 95%CI, 0.963–0.991; p = .001), and SII (aOR, 0.999; 95%CI, 0.998–1.000; p = .040) were protective factors. A combination of age, PD vintage, Gram-positive peritonitis, staphylococcus aureus, culture-negative, NLR, PLR, HLR, and SII would improve prognostic performance. The area under this ROC curve was 0.85, higher than other factors.Conclusions NLR, PLR, HLR, and SII were associated with PDAP outcomes. Age, PD vintage, NLR, and PLR were significant risk factors in PDAP patients.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2179856Peritoneal dialysisperitonitisneutrophil-to-lymphocyte ratio (NLR)platelet-to-lymphocyte ratio (PLR)hemoglobin-to-lymphocyte ratio (HLR) |
| spellingShingle | Dan Zhou Huibin Yang Li Zeng Wei Yang Fujia Guo Wenting Cui Cong Chen Jiayao Zhao Shuran Wu Ning Yang Hongli Lin Anchun Yin Longkai Li Calculated inflammatory markers derived from complete blood count results, along with routine laboratory and clinical data, predict treatment failure of acute peritonitis in chronic peritoneal dialysis patients Renal Failure Peritoneal dialysis peritonitis neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte ratio (PLR) hemoglobin-to-lymphocyte ratio (HLR) |
| title | Calculated inflammatory markers derived from complete blood count results, along with routine laboratory and clinical data, predict treatment failure of acute peritonitis in chronic peritoneal dialysis patients |
| title_full | Calculated inflammatory markers derived from complete blood count results, along with routine laboratory and clinical data, predict treatment failure of acute peritonitis in chronic peritoneal dialysis patients |
| title_fullStr | Calculated inflammatory markers derived from complete blood count results, along with routine laboratory and clinical data, predict treatment failure of acute peritonitis in chronic peritoneal dialysis patients |
| title_full_unstemmed | Calculated inflammatory markers derived from complete blood count results, along with routine laboratory and clinical data, predict treatment failure of acute peritonitis in chronic peritoneal dialysis patients |
| title_short | Calculated inflammatory markers derived from complete blood count results, along with routine laboratory and clinical data, predict treatment failure of acute peritonitis in chronic peritoneal dialysis patients |
| title_sort | calculated inflammatory markers derived from complete blood count results along with routine laboratory and clinical data predict treatment failure of acute peritonitis in chronic peritoneal dialysis patients |
| topic | Peritoneal dialysis peritonitis neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte ratio (PLR) hemoglobin-to-lymphocyte ratio (HLR) |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2179856 |
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