Tumour lysis syndrome: A rare acute presentation of locally advanced testicular cancer – Case report and review of literature
Tumour lysis syndrome (TLS) is a potentially fatal complication of malignancy or its treatment. This uncommon syndrome comprises laboratory findings of hyperuricaemia, hypocalcaemia, hyperkalaemia and hyperphosphataemia. A literature search revealed a total of eight patients, with testicular cancer,...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | Asian Journal of Urology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388215001137 |
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| _version_ | 1850104380748988416 |
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| author | Marcus Chow Arianto Yuwono Ronny Tan |
| author_facet | Marcus Chow Arianto Yuwono Ronny Tan |
| author_sort | Marcus Chow |
| collection | DOAJ |
| description | Tumour lysis syndrome (TLS) is a potentially fatal complication of malignancy or its treatment. This uncommon syndrome comprises laboratory findings of hyperuricaemia, hypocalcaemia, hyperkalaemia and hyperphosphataemia. A literature search revealed a total of eight patients, with testicular cancer, who had TLS. All these patients had metastatic disease. We present a unique case of a 47-year-old gentleman we saw in clinic, who presented with a rapidly growing right groin mass and acute breathlessness, and discuss the diagnosis and management of TLS. TLS is extremely rare in testicular cancer but necessitates the awareness of urologists. TLS can occur spontaneously in testicular malignancy. Cell lysis in a rapidly proliferating germ cell tumour is a possible mechanism. The prompt identification and institution of management for TLS is crucial to improve clinical outcomes. |
| format | Article |
| id | doaj-art-4716e5ca75ea454681ef286744c07f40 |
| institution | DOAJ |
| issn | 2214-3882 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj-art-4716e5ca75ea454681ef286744c07f402025-08-20T02:39:20ZengElsevierAsian Journal of Urology2214-38822016-01-0131495210.1016/j.ajur.2015.09.005Tumour lysis syndrome: A rare acute presentation of locally advanced testicular cancer – Case report and review of literatureMarcus ChowArianto YuwonoRonny TanTumour lysis syndrome (TLS) is a potentially fatal complication of malignancy or its treatment. This uncommon syndrome comprises laboratory findings of hyperuricaemia, hypocalcaemia, hyperkalaemia and hyperphosphataemia. A literature search revealed a total of eight patients, with testicular cancer, who had TLS. All these patients had metastatic disease. We present a unique case of a 47-year-old gentleman we saw in clinic, who presented with a rapidly growing right groin mass and acute breathlessness, and discuss the diagnosis and management of TLS. TLS is extremely rare in testicular cancer but necessitates the awareness of urologists. TLS can occur spontaneously in testicular malignancy. Cell lysis in a rapidly proliferating germ cell tumour is a possible mechanism. The prompt identification and institution of management for TLS is crucial to improve clinical outcomes.http://www.sciencedirect.com/science/article/pii/S2214388215001137Tumour lysis syndromeTesticular cancerTesticular malignancy |
| spellingShingle | Marcus Chow Arianto Yuwono Ronny Tan Tumour lysis syndrome: A rare acute presentation of locally advanced testicular cancer – Case report and review of literature Asian Journal of Urology Tumour lysis syndrome Testicular cancer Testicular malignancy |
| title | Tumour lysis syndrome: A rare acute presentation of locally advanced testicular cancer – Case report and review of literature |
| title_full | Tumour lysis syndrome: A rare acute presentation of locally advanced testicular cancer – Case report and review of literature |
| title_fullStr | Tumour lysis syndrome: A rare acute presentation of locally advanced testicular cancer – Case report and review of literature |
| title_full_unstemmed | Tumour lysis syndrome: A rare acute presentation of locally advanced testicular cancer – Case report and review of literature |
| title_short | Tumour lysis syndrome: A rare acute presentation of locally advanced testicular cancer – Case report and review of literature |
| title_sort | tumour lysis syndrome a rare acute presentation of locally advanced testicular cancer case report and review of literature |
| topic | Tumour lysis syndrome Testicular cancer Testicular malignancy |
| url | http://www.sciencedirect.com/science/article/pii/S2214388215001137 |
| work_keys_str_mv | AT marcuschow tumourlysissyndromearareacutepresentationoflocallyadvancedtesticularcancercasereportandreviewofliterature AT ariantoyuwono tumourlysissyndromearareacutepresentationoflocallyadvancedtesticularcancercasereportandreviewofliterature AT ronnytan tumourlysissyndromearareacutepresentationoflocallyadvancedtesticularcancercasereportandreviewofliterature |