Perirhinal Cortex Neuronal Activity is Actively Related to Working Memory in the Macaque
Lesion studies suggest that the perirhinai cortex plays a role in object recognition memory. To analyze its role, we recorded the activity of single neurons in the perirhinal cortex in a rhesus monkey (Macaca mulatta) performing a delayed matching-to-sample task with up to four intervening stimuli....
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2002-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2002.41 |
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| _version_ | 1849405131109433344 |
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| author | Christian Hölscher Edmund T. Rolls |
| author_facet | Christian Hölscher Edmund T. Rolls |
| author_sort | Christian Hölscher |
| collection | DOAJ |
| description | Lesion studies suggest that the perirhinai
cortex plays a role in object recognition memory.
To analyze its role, we recorded the activity of
single neurons in the perirhinal cortex in a
rhesus monkey (Macaca mulatta) performing a
delayed matching-to-sample task with up to four
intervening stimuli. Certain neurons (40 of 90
analyzed) showed a smaller response to an image
when it was shown the second time within a trial
(as a match image) than when it had been shown
(as a sample image) the first time. A new finding
was that the perirhinal cortex neurons were
actively reset between trials: when a particular
image was shown as a sample on a succeeding
trial, the response was much larger than when it
had been shown as a match image a short time
previously on the previous trial. This resetting
between trials appears to reflect the operation of
an active working memory process rather than a
passive temporal decay in a neuronal response.
The results thus provide evidence that the
perirhinal cortex plays an active role in visual
working memory, perhaps in association with
other brain areas such as the prefrontal cortex. |
| format | Article |
| id | doaj-art-47142b28b8dd4d5ebd2c78e874c7ab6a |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-47142b28b8dd4d5ebd2c78e874c7ab6a2025-08-20T03:36:45ZengWileyNeural Plasticity2090-59041687-54432002-01-0191415110.1155/NP.2002.41Perirhinal Cortex Neuronal Activity is Actively Related to Working Memory in the MacaqueChristian Hölscher0Edmund T. Rolls1Oxford University, Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, UKOxford University, Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, UKLesion studies suggest that the perirhinai cortex plays a role in object recognition memory. To analyze its role, we recorded the activity of single neurons in the perirhinal cortex in a rhesus monkey (Macaca mulatta) performing a delayed matching-to-sample task with up to four intervening stimuli. Certain neurons (40 of 90 analyzed) showed a smaller response to an image when it was shown the second time within a trial (as a match image) than when it had been shown (as a sample image) the first time. A new finding was that the perirhinal cortex neurons were actively reset between trials: when a particular image was shown as a sample on a succeeding trial, the response was much larger than when it had been shown as a match image a short time previously on the previous trial. This resetting between trials appears to reflect the operation of an active working memory process rather than a passive temporal decay in a neuronal response. The results thus provide evidence that the perirhinal cortex plays an active role in visual working memory, perhaps in association with other brain areas such as the prefrontal cortex.http://dx.doi.org/10.1155/NP.2002.41 |
| spellingShingle | Christian Hölscher Edmund T. Rolls Perirhinal Cortex Neuronal Activity is Actively Related to Working Memory in the Macaque Neural Plasticity |
| title | Perirhinal Cortex Neuronal Activity is Actively Related to
Working Memory in the Macaque |
| title_full | Perirhinal Cortex Neuronal Activity is Actively Related to
Working Memory in the Macaque |
| title_fullStr | Perirhinal Cortex Neuronal Activity is Actively Related to
Working Memory in the Macaque |
| title_full_unstemmed | Perirhinal Cortex Neuronal Activity is Actively Related to
Working Memory in the Macaque |
| title_short | Perirhinal Cortex Neuronal Activity is Actively Related to
Working Memory in the Macaque |
| title_sort | perirhinal cortex neuronal activity is actively related to working memory in the macaque |
| url | http://dx.doi.org/10.1155/NP.2002.41 |
| work_keys_str_mv | AT christianholscher perirhinalcortexneuronalactivityisactivelyrelatedtoworkingmemoryinthemacaque AT edmundtrolls perirhinalcortexneuronalactivityisactivelyrelatedtoworkingmemoryinthemacaque |