Review of Two Siblings with Werner's Syndrome: A Case Report
We report the clinical course of two siblings with Werner's syndrome (WS) who were diagnosed and followed at our clinics for 12 years. Initial diagnosis of the first sibling (sister) was at age 20, the second (brother) at 16. At the initial diagnosis, the sister had amenorrhea, muscle atrophy a...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2009/138312 |
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| _version_ | 1850104436621312000 |
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| author | Murat Sert Koray Fakioglu Tamer Tetiker |
| author_facet | Murat Sert Koray Fakioglu Tamer Tetiker |
| author_sort | Murat Sert |
| collection | DOAJ |
| description | We report the clinical course of two siblings with Werner's syndrome (WS) who were diagnosed and followed at our clinics for 12 years. Initial diagnosis of the first sibling (sister) was at age 20, the second (brother) at 16. At the initial diagnosis, the sister had amenorrhea, muscle atrophy at arms and legs, diabetes mellitus (DM), short stature, bilateral cataracts, genital hypoplasia, osteoporosis, and gray hair. During 12 years follow-up period, high-pitched voice, hepatosteatosis, renal parenchymal disease, and urethral obstruction developed. Regarding the brother, DM, cataracts and genital hypoplasia were observed at the initial diagnosis. During the 12 years follow-up period, gray hair, high-pitched voice, steatohepatosis, and osteoporosis developed. |
| format | Article |
| id | doaj-art-470f71d14cbd472aaf7fde27e8eb12ed |
| institution | DOAJ |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-470f71d14cbd472aaf7fde27e8eb12ed2025-08-20T02:39:19ZengWileyCase Reports in Medicine1687-96271687-96352009-01-01200910.1155/2009/138312138312Review of Two Siblings with Werner's Syndrome: A Case ReportMurat Sert0Koray Fakioglu1Tamer Tetiker2Division of Endocrinology, Department of Internal Medicine, Medical Faculty, Cukurova University, 01330 Adana, TurkeyDivision of Endocrinology, Department of Internal Medicine, Medical Faculty, Cukurova University, 01330 Adana, TurkeyDivision of Endocrinology, Department of Internal Medicine, Medical Faculty, Cukurova University, 01330 Adana, TurkeyWe report the clinical course of two siblings with Werner's syndrome (WS) who were diagnosed and followed at our clinics for 12 years. Initial diagnosis of the first sibling (sister) was at age 20, the second (brother) at 16. At the initial diagnosis, the sister had amenorrhea, muscle atrophy at arms and legs, diabetes mellitus (DM), short stature, bilateral cataracts, genital hypoplasia, osteoporosis, and gray hair. During 12 years follow-up period, high-pitched voice, hepatosteatosis, renal parenchymal disease, and urethral obstruction developed. Regarding the brother, DM, cataracts and genital hypoplasia were observed at the initial diagnosis. During the 12 years follow-up period, gray hair, high-pitched voice, steatohepatosis, and osteoporosis developed.http://dx.doi.org/10.1155/2009/138312 |
| spellingShingle | Murat Sert Koray Fakioglu Tamer Tetiker Review of Two Siblings with Werner's Syndrome: A Case Report Case Reports in Medicine |
| title | Review of Two Siblings with Werner's Syndrome: A Case Report |
| title_full | Review of Two Siblings with Werner's Syndrome: A Case Report |
| title_fullStr | Review of Two Siblings with Werner's Syndrome: A Case Report |
| title_full_unstemmed | Review of Two Siblings with Werner's Syndrome: A Case Report |
| title_short | Review of Two Siblings with Werner's Syndrome: A Case Report |
| title_sort | review of two siblings with werner s syndrome a case report |
| url | http://dx.doi.org/10.1155/2009/138312 |
| work_keys_str_mv | AT muratsert reviewoftwosiblingswithwernerssyndromeacasereport AT korayfakioglu reviewoftwosiblingswithwernerssyndromeacasereport AT tamertetiker reviewoftwosiblingswithwernerssyndromeacasereport |