Leptin signalling altered in infantile nephropathic cystinosis‐related bone disorder

Leptin signalling altered in infantile nephropathic cystinosis‐related bone disorder

Abstract Background The CTNS gene mutation causes infantile nephropathic cystinosis (INC). Patients with INC develop Fanconi syndrome and chronic kidney disease (CKD) with significant bone deformations. C57BL/6 Ctns−/− mice are an animal model for studying INC. Hyperleptinaemia results from the kidn...

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Bibliographic Details
Main Authors: Wai W. Cheung, Ping Zhou, Ronghao Zheng, Arieh Gertler, Eduardo A. Oliveira, Robert H. Mak
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
AgRP
Bone
Infantile nephropathic cystinosis
Leptin
Melanocortin receptor
Online Access:https://doi.org/10.1002/jcsm.13579
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