Predictive factors of cytomegalovirus seropositivity among pregnant women in Paris, France.
<h4>Background</h4>Cytomegalovirus (CMV) is the most frequent cause of congenital infection. The objective of this study was to evaluate predictive factors for CMV seronegativity in a cohort of pregnant women in Paris, France.<h4>Methods</h4>Pregnant women enrolled in a prosp...
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089857&type=printable |
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| author | Dieynaba S N'Diaye Yazdan Yazdanpanah Anne Krivine Thibaut Andrieu Flore Rozenberg Olivier Picone Vassilis Tsatsaris François Goffinet Odile Launay |
| author_facet | Dieynaba S N'Diaye Yazdan Yazdanpanah Anne Krivine Thibaut Andrieu Flore Rozenberg Olivier Picone Vassilis Tsatsaris François Goffinet Odile Launay |
| author_sort | Dieynaba S N'Diaye |
| collection | DOAJ |
| description | <h4>Background</h4>Cytomegalovirus (CMV) is the most frequent cause of congenital infection. The objective of this study was to evaluate predictive factors for CMV seronegativity in a cohort of pregnant women in Paris, France.<h4>Methods</h4>Pregnant women enrolled in a prospective cohort during the 2009 A/H1N1 pandemic were tested for CMV IgG antibodies. Variables collected were age, geographic origin, lifestyle, work characteristics, socioeconomic status, gravidity, parity and number of children at home. A multivariate logistic regression model was used to identify independent predictive factors for CMV seropositivity.<h4>Results</h4>Among the 826 women enrolled, 389 (47.1%) were primiparous, and 552 (67.1%) had Metropolitan France as a geographic origin. Out of these, 355 (i.e. 57.0%, 95% confidence interval (CI): [53.6%-60.4%]) were CMV seropositive: 43.7% (95% CI:[39.5%-47.9%]) in those whose geographic origin was Metropolitan France and 84.1% in those with other origins (95% CI:[79.2%-88.3%]). Determinants associated with CMV seropositivity in a multivariate logistic regression model were: (i) geographic origin (p<0.001(compared with Metropolitan France, geographic origins of Africa adjusted odds ratio (aOR) 21.2, 95% CI:[9.7-46.5], French overseas departments and territories and other origin, aOR 7.5, 95% CI:[3.9-14.6], and Europe or Asia, aOR 2.2, 95% CI: [1.3-3.7]); and (ii) gravidity (p = 0.019), (compared with gravidity = 1, if gravidity≥3, aOR = 1.5, 95% CI: [1.1-2.2]; if gravidity = 2, aOR = 1.0, 95% CI: [0.7-1.4]). Work characteristics and socioeconomic status were not independently associated with CMV seropositivity.<h4>Conclusions</h4>In this cohort of pregnant women, a geographic origin of Metropolitan France and a low gravidity were predictive factors for CMV low seropositivity. Such women are therefore the likely target population for prevention of CMV infection during pregnancy in France. |
| format | Article |
| id | doaj-art-470624846cd147f8a160f8a9b63b5807 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-470624846cd147f8a160f8a9b63b58072025-08-20T03:11:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0192e8985710.1371/journal.pone.0089857Predictive factors of cytomegalovirus seropositivity among pregnant women in Paris, France.Dieynaba S N'DiayeYazdan YazdanpanahAnne KrivineThibaut AndrieuFlore RozenbergOlivier PiconeVassilis TsatsarisFrançois GoffinetOdile Launay<h4>Background</h4>Cytomegalovirus (CMV) is the most frequent cause of congenital infection. The objective of this study was to evaluate predictive factors for CMV seronegativity in a cohort of pregnant women in Paris, France.<h4>Methods</h4>Pregnant women enrolled in a prospective cohort during the 2009 A/H1N1 pandemic were tested for CMV IgG antibodies. Variables collected were age, geographic origin, lifestyle, work characteristics, socioeconomic status, gravidity, parity and number of children at home. A multivariate logistic regression model was used to identify independent predictive factors for CMV seropositivity.<h4>Results</h4>Among the 826 women enrolled, 389 (47.1%) were primiparous, and 552 (67.1%) had Metropolitan France as a geographic origin. Out of these, 355 (i.e. 57.0%, 95% confidence interval (CI): [53.6%-60.4%]) were CMV seropositive: 43.7% (95% CI:[39.5%-47.9%]) in those whose geographic origin was Metropolitan France and 84.1% in those with other origins (95% CI:[79.2%-88.3%]). Determinants associated with CMV seropositivity in a multivariate logistic regression model were: (i) geographic origin (p<0.001(compared with Metropolitan France, geographic origins of Africa adjusted odds ratio (aOR) 21.2, 95% CI:[9.7-46.5], French overseas departments and territories and other origin, aOR 7.5, 95% CI:[3.9-14.6], and Europe or Asia, aOR 2.2, 95% CI: [1.3-3.7]); and (ii) gravidity (p = 0.019), (compared with gravidity = 1, if gravidity≥3, aOR = 1.5, 95% CI: [1.1-2.2]; if gravidity = 2, aOR = 1.0, 95% CI: [0.7-1.4]). Work characteristics and socioeconomic status were not independently associated with CMV seropositivity.<h4>Conclusions</h4>In this cohort of pregnant women, a geographic origin of Metropolitan France and a low gravidity were predictive factors for CMV low seropositivity. Such women are therefore the likely target population for prevention of CMV infection during pregnancy in France.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089857&type=printable |
| spellingShingle | Dieynaba S N'Diaye Yazdan Yazdanpanah Anne Krivine Thibaut Andrieu Flore Rozenberg Olivier Picone Vassilis Tsatsaris François Goffinet Odile Launay Predictive factors of cytomegalovirus seropositivity among pregnant women in Paris, France. PLoS ONE |
| title | Predictive factors of cytomegalovirus seropositivity among pregnant women in Paris, France. |
| title_full | Predictive factors of cytomegalovirus seropositivity among pregnant women in Paris, France. |
| title_fullStr | Predictive factors of cytomegalovirus seropositivity among pregnant women in Paris, France. |
| title_full_unstemmed | Predictive factors of cytomegalovirus seropositivity among pregnant women in Paris, France. |
| title_short | Predictive factors of cytomegalovirus seropositivity among pregnant women in Paris, France. |
| title_sort | predictive factors of cytomegalovirus seropositivity among pregnant women in paris france |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089857&type=printable |
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