Development of an oral regimen of unithiol for the treatment of snakebite envenoming: a phase 1 open-label dose-escalation safety trial and pharmacokinetic analysis in healthy Kenyan adultsResearch in context

Development of an oral regimen of unithiol for the treatment of snakebite envenoming: a phase 1 open-label dose-escalation safety trial and pharmacokinetic analysis in healthy Kenyan adultsResearch in context

Summary: Background: Viperidae snakes are responsible for many of the 94,000 deaths caused by snakebite envenoming each year. The most pathological venom component of this globally diverse family of snakes are the zinc-dependent snake venom metalloproteinase (SVMP) enzymes, which can be inhibited b...

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Main Authors: Michael Abouyannis, Yvonne K. Nyambura, Samson Ngome, Debra Riako, Jennifer Musyoki, Charles Muiruri, Benedict Orindi, Laura Else, Alieu Amara, Laura Dickinson, Rachel H. Clare, Laura-Oana Albulescu, Adam P. Westhorpe, Jeroen Kool, Ifedayo Adetifa, Francis M. Ndungu, Richard FitzGerald, Saye Khoo, David G. Lalloo, Nicholas R. Casewell, Mainga Hamaluba
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:EBioMedicine
Subjects:
Phase 1 clinical trial
Snakebite
Envenoming
Unithiol
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425000441
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