Giant renal oncocytoma
Background. Renal onkocytoma is a distinctive benign tumor derived from epithelial cells of the distal renal tubules. These tumors are often clinically asymptomatic, diagnosed accidentally and difficult to distinguish from renal cell carcinoma. Case report. We presented a giant renal onkocytoma...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2013-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501301068S.pdf |
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| author | Stojanović Nebojša Ignjatović Ivan Kostov Miloš Mijović Žaklina Živković Sladjana Košević Branko |
| author_facet | Stojanović Nebojša Ignjatović Ivan Kostov Miloš Mijović Žaklina Živković Sladjana Košević Branko |
| author_sort | Stojanović Nebojša |
| collection | DOAJ |
| description | Background. Renal onkocytoma is a distinctive benign tumor derived from epithelial cells of the distal renal tubules. These tumors are often clinically asymptomatic, diagnosed accidentally and difficult to distinguish from renal cell carcinoma. Case report. We presented a giant renal onkocytoma in a man aged 64, without any signs or symptoms of the urogenital system disorder. The preoperative diagnosis described the tumor mass of the right kidney, size 16 x 14 cm, and indicated a malignant tumor of kidney. The patient underwent radical nephrectomy. The tumor was encapsulated at the intersection with the characteristic central hyaline scar. Microscopically, it was built of uniform polygonal cells with abundant eosinophilic cytoplasm. Immunohystochemiclly, tumor cells were immunoreactive to CK AE1/AE3 and CD 117, but showed negative immunoreactivity to CK 7, RCC marker and Vimentin. Conclusion. Giant renal oncocytomas are rare tumors with benign clinical course. As a rule, they are discovered by accident. Clinical differentiation from malignant tumors of the kidney is not possible. They are treated surgically, mainly by radical nephrectomy. A definitive diagnosis is made only by histopathological examination of tumors using immunohistochemical marker panels. |
| format | Article |
| id | doaj-art-4703c4316fff4a678edf76296cb1b4e7 |
| institution | OA Journals |
| issn | 0042-8450 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-4703c4316fff4a678edf76296cb1b4e72025-08-20T01:56:34ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502013-01-01701687110.2298/VSP1301068SGiant renal oncocytomaStojanović NebojšaIgnjatović IvanKostov MilošMijović ŽaklinaŽivković SladjanaKošević BrankoBackground. Renal onkocytoma is a distinctive benign tumor derived from epithelial cells of the distal renal tubules. These tumors are often clinically asymptomatic, diagnosed accidentally and difficult to distinguish from renal cell carcinoma. Case report. We presented a giant renal onkocytoma in a man aged 64, without any signs or symptoms of the urogenital system disorder. The preoperative diagnosis described the tumor mass of the right kidney, size 16 x 14 cm, and indicated a malignant tumor of kidney. The patient underwent radical nephrectomy. The tumor was encapsulated at the intersection with the characteristic central hyaline scar. Microscopically, it was built of uniform polygonal cells with abundant eosinophilic cytoplasm. Immunohystochemiclly, tumor cells were immunoreactive to CK AE1/AE3 and CD 117, but showed negative immunoreactivity to CK 7, RCC marker and Vimentin. Conclusion. Giant renal oncocytomas are rare tumors with benign clinical course. As a rule, they are discovered by accident. Clinical differentiation from malignant tumors of the kidney is not possible. They are treated surgically, mainly by radical nephrectomy. A definitive diagnosis is made only by histopathological examination of tumors using immunohistochemical marker panels.http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501301068S.pdfkidney neoplasmsdiagnosis, differentialadenoma, oxyphilicdiagnosishistological techniquessurgical procedures, operative |
| spellingShingle | Stojanović Nebojša Ignjatović Ivan Kostov Miloš Mijović Žaklina Živković Sladjana Košević Branko Giant renal oncocytoma Vojnosanitetski Pregled kidney neoplasms diagnosis, differential adenoma, oxyphilic diagnosis histological techniques surgical procedures, operative |
| title | Giant renal oncocytoma |
| title_full | Giant renal oncocytoma |
| title_fullStr | Giant renal oncocytoma |
| title_full_unstemmed | Giant renal oncocytoma |
| title_short | Giant renal oncocytoma |
| title_sort | giant renal oncocytoma |
| topic | kidney neoplasms diagnosis, differential adenoma, oxyphilic diagnosis histological techniques surgical procedures, operative |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501301068S.pdf |
| work_keys_str_mv | AT stojanovicnebojsa giantrenaloncocytoma AT ignjatovicivan giantrenaloncocytoma AT kostovmilos giantrenaloncocytoma AT mijoviczaklina giantrenaloncocytoma AT zivkovicsladjana giantrenaloncocytoma AT kosevicbranko giantrenaloncocytoma |