Jian Pi Hua Tan Fang Reverses Trastuzumab Resistance of HER2‐Positive Gastric Cancer Through PI3K/AKT/mTOR Pathway: Integrating Network Pharmacology, Molecular Docking and Experimental Validation

Jian Pi Hua Tan Fang Reverses Trastuzumab Resistance of HER2‐Positive Gastric Cancer Through PI3K/AKT/mTOR Pathway: Integrating Network Pharmacology, Molecular Docking and Experimental Validation

ABSTRACT Background Currently, trastuzumab resistance significantly impacts the treatment outcome for individuals with HER2‐positive gastric cancer. In clinical practice, Jian Pi Hua Tan Fang (JPHTF) has been shown to be effective in preventing recurrences and metastases caused by gastric cancer. Ye...

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Bibliographic Details
Main Authors:	Jia Hu, Wenjing Bu, Yongfang Ding, Xin Li, Bo Zhang, Bo Shen, Cong Wu, Youqi Xu, Xiaoyang Zhang
Format:	Article
Language:	English
Published:	Wiley 2025-02-01
Series:	Immunity, Inflammation and Disease
Subjects:	HER2‐positive gastric cancer Jian Pi Hua Tan Fang molecular docking network pharmacology PI3K/AKT/mTOR pathway Trastuzumab resistance
Online Access:	https://doi.org/10.1002/iid3.70154
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