Dose-Limiting Toxicities and the Maximum Tolerated Dose of Irinotecan Based on <i>UGT1A1</i> Genotypes: A Systematic Review

Dose-Limiting Toxicities and the Maximum Tolerated Dose of Irinotecan Based on <i>UGT1A1</i> Genotypes: A Systematic Review

<b>Background/Objectives:</b> Irinotecan is used in monotherapy or combined with other drugs for treating different cancer streams. SN-38, the active metabolite of irinotecan, is 70% inactivated by the uridine diphosphate (UDP) glucuronosyltransferase family 1 member A1 (UGT1A1) enzyme....

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Main Authors:	Xando Díaz-Villamarín, María Teresa Nieto-Sánchez, María Martínez-Pérez, Paula Novo-González, Emilio Fernández-Varón, Alicia Torres-García, Beatriz González Astorga, Isabel Blancas, José Cabeza-Barrera, Rocío Morón
Format:	Article
Language:	English
Published:	MDPI AG 2025-04-01
Series:	Pharmaceutics
Subjects:	irinotecan <i>UGT1A1</i> maximum tolerated dose pharmacogenetics pharmacogenomic personalized medicine
Online Access:	https://www.mdpi.com/1999-4923/17/5/542
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