Palliative long-term abdominal drains vs. large volume paracentesis for refractory ascites secondary to cirrhosis: protocol for a definitive randomised controlled trial (REDUCe2 study)

Palliative long-term abdominal drains vs. large volume paracentesis for refractory ascites secondary to cirrhosis: protocol for a definitive randomised controlled trial (REDUCe2 study)

Abstract Background Ascites remains the most common complication of cirrhosis and a frequent reason for hospitalisation in advanced chronic liver disease (ACLD). Ascites is associated with significant symptom burden, caregiver workload and poor health-related quality of life (HRQoL). Once refractory...

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Main Authors: Yazan Haddadin, Vasso Anagnostopoulou, Stephen Bremner, Helena Harder, Rachel Starkings, Debbie Lambert, Alison Porges, Nicky Perry, Wendy Wood, Amy Arbon, Heather Gage, Matthew Glover, Lucia Macken, Malcolm Johnston, Bhaskar Ganai, Dhiraj Joshi, Ben Hudson, Claire Butler, Alison Richardson, Mark Wright, Wendy Prentice, Alastair O’Brien, Joan Bedlington, Shani Steer, Tom Gaskin, Sumita Verma
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Trials
Subjects:
Ascites
End-stage liver disease
Paracentesis
Palliative care
Quality of life
Caregivers
Online Access:https://doi.org/10.1186/s13063-025-08873-z
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