Comprehensive numerical prototyping of paper-based microfluidic devices using open-source tools
Paper-based microfluidics has emerged as a promising field with diverse applications ranging from medical diagnostics to environmental monitoring. Despite significant progress in research and development, the translation of paper-based prototypes into practical end-user devices remains limited. This...
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Elsevier
2024-12-01
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| Series: | Talanta Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266683192400064X |
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| author | Gabriel S. Gerlero Zahar I. Guerenstein Nicolás Franck Claudio L.A. Berli Pablo A. Kler |
| author_facet | Gabriel S. Gerlero Zahar I. Guerenstein Nicolás Franck Claudio L.A. Berli Pablo A. Kler |
| author_sort | Gabriel S. Gerlero |
| collection | DOAJ |
| description | Paper-based microfluidics has emerged as a promising field with diverse applications ranging from medical diagnostics to environmental monitoring. Despite significant progress in research and development, the translation of paper-based prototypes into practical end-user devices remains limited. This limitation stems from challenges related to devices not being sufficiently portable and autonomous, which paper-based microfluidics is expected to overcome. Yet for this purpose, we note the lack of comprehensive numerical modeling tools capable of simulating the intricate physicochemical phenomena involved in order to optimize the development process; hence, in this study, we introduce porousMicroTransport, a novel simulation package integrated with the open-source platform OpenFOAM®, designed to address these challenges. porousMicroTransport offers efficient solvers for fluid flow and transport phenomena in microfluidic porous media, including capillarity models and (bio)chemical reactions. Moreover, under horizontal flow conditions, porousMicroTransport application field can be extended to any porous media. We demonstrate the software’s effectiveness in two example cases, showcasing its ability to accurately reproduce complex phenomena involved in paper-based devices. By virtue of being an easy-to-use and computationally efficient tool, porousMicroTransport facilitates the design and optimization of devices, potentially enabling more devices to meet the WHO’s REASSURED criteria for point-of-care testing. We anticipate that this tool will accelerate the development and deployment of robust and portable diagnostic devices, bridging the gap between research and practical applications. |
| format | Article |
| id | doaj-art-46f89f5f6d704ff3a71b90fcf19b2ed8 |
| institution | OA Journals |
| issn | 2666-8319 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Talanta Open |
| spelling | doaj-art-46f89f5f6d704ff3a71b90fcf19b2ed82025-08-20T01:59:35ZengElsevierTalanta Open2666-83192024-12-011010035010.1016/j.talo.2024.100350Comprehensive numerical prototyping of paper-based microfluidic devices using open-source toolsGabriel S. Gerlero0Zahar I. Guerenstein1Nicolás Franck2Claudio L.A. Berli3Pablo A. Kler4Centro de Investigación de Métodos Computacionales (CIMEC, UNL–CONICET), Colectora RN 168 km 472, Santa Fe, (3000), Argentina; Universidad Nacional de Rafaela, Bv. Roca 989, Rafaela, (2300), ArgentinaDepartamento de Ingenieria Mecánica, Facultad Regional Santa Fe, Universidad Tecnológica Nacional, Lavaisse 610, Santa Fe, (3000), ArgentinaCentro de Investigación de Métodos Computacionales (CIMEC, UNL–CONICET), Colectora RN 168 km 472, Santa Fe, (3000), Argentina; Departamento de Ingenieria en Sistemas de Información, Facultad Regional Santa Fe, Universidad Tecnológica Nacional, Lavaisse 610, Santa Fe, (3000), ArgentinaInstituto de Desarrollo Tecnológico para la Industria Quimica (INTEC, UNL–CONICET), Colectora RN 168 km 472, Santa Fe, (3000), ArgentinaCorresponding author.; Centro de Investigación de Métodos Computacionales (CIMEC, UNL–CONICET), Colectora RN 168 km 472, Santa Fe, (3000), Argentina; Departamento de Ingenieria en Sistemas de Información, Facultad Regional Santa Fe, Universidad Tecnológica Nacional, Lavaisse 610, Santa Fe, (3000), ArgentinaPaper-based microfluidics has emerged as a promising field with diverse applications ranging from medical diagnostics to environmental monitoring. Despite significant progress in research and development, the translation of paper-based prototypes into practical end-user devices remains limited. This limitation stems from challenges related to devices not being sufficiently portable and autonomous, which paper-based microfluidics is expected to overcome. Yet for this purpose, we note the lack of comprehensive numerical modeling tools capable of simulating the intricate physicochemical phenomena involved in order to optimize the development process; hence, in this study, we introduce porousMicroTransport, a novel simulation package integrated with the open-source platform OpenFOAM®, designed to address these challenges. porousMicroTransport offers efficient solvers for fluid flow and transport phenomena in microfluidic porous media, including capillarity models and (bio)chemical reactions. Moreover, under horizontal flow conditions, porousMicroTransport application field can be extended to any porous media. We demonstrate the software’s effectiveness in two example cases, showcasing its ability to accurately reproduce complex phenomena involved in paper-based devices. By virtue of being an easy-to-use and computationally efficient tool, porousMicroTransport facilitates the design and optimization of devices, potentially enabling more devices to meet the WHO’s REASSURED criteria for point-of-care testing. We anticipate that this tool will accelerate the development and deployment of robust and portable diagnostic devices, bridging the gap between research and practical applications.http://www.sciencedirect.com/science/article/pii/S266683192400064XPaper-based microfluidicsNumerical prototypingComputer simulationsmicro-Toatal Analysys SystemsImmunoassays |
| spellingShingle | Gabriel S. Gerlero Zahar I. Guerenstein Nicolás Franck Claudio L.A. Berli Pablo A. Kler Comprehensive numerical prototyping of paper-based microfluidic devices using open-source tools Talanta Open Paper-based microfluidics Numerical prototyping Computer simulations micro-Toatal Analysys Systems Immunoassays |
| title | Comprehensive numerical prototyping of paper-based microfluidic devices using open-source tools |
| title_full | Comprehensive numerical prototyping of paper-based microfluidic devices using open-source tools |
| title_fullStr | Comprehensive numerical prototyping of paper-based microfluidic devices using open-source tools |
| title_full_unstemmed | Comprehensive numerical prototyping of paper-based microfluidic devices using open-source tools |
| title_short | Comprehensive numerical prototyping of paper-based microfluidic devices using open-source tools |
| title_sort | comprehensive numerical prototyping of paper based microfluidic devices using open source tools |
| topic | Paper-based microfluidics Numerical prototyping Computer simulations micro-Toatal Analysys Systems Immunoassays |
| url | http://www.sciencedirect.com/science/article/pii/S266683192400064X |
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