D-2-hydroxyglutarate impairs DNA repair through epigenetic reprogramming

D-2-hydroxyglutarate impairs DNA repair through epigenetic reprogramming

Abstract Cancer-associated mutations in IDH are associated with multiple types of human malignancies, which exhibit distinctive metabolic reprogramming, production of oncometabolite D-2-HG, and shifted epigenetic landscape. IDH mutated malignancies are signatured with “BRCAness”, highlighted with th...

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Bibliographic Details
Main Authors: Fengchao Lang, Karambir Kaur, Haiqing Fu, Javeria Zaheer, Diego Luis Ribeiro, Mirit I. Aladjem, Chunzhang Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56781-2
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