Redox-Driven Epigenetic Modifications in Sperm: Unraveling Paternal Influences on Embryo Development and Transgenerational Health

Redox-Driven Epigenetic Modifications in Sperm: Unraveling Paternal Influences on Embryo Development and Transgenerational Health

Male-factor infertility accounts for nearly half of all infertility cases, and mounting evidence points to oxidative stress as a pivotal driver of sperm dysfunction, genetic instability, and epigenetic dysregulation. In particular, the oxidative DNA lesion 8-hydroxy-2′-deoxyguanosine (8-OHdG) has em...

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Bibliographic Details
Main Authors: Aron Moazamian, Fabrice Saez, Joël R. Drevet, Robert John Aitken, Parviz Gharagozloo
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Antioxidants
Subjects:
male infertility
oxidative stress
sperm DNA damage
epigenetics
8-hydroxy-2′-deoxyguanosine (8-OHdG)
embryo development
Online Access:https://www.mdpi.com/2076-3921/14/5/570
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