Molecular mechanism of aberrant decidualization in adenomyosis leading to reduced endometrial receptivity
Patients with adenomyosis not only experience a decrease in quality of life as a result of dysmenorrhea and severe monthly flow but they are also rendered infertile. Pregnancy rates are still low among women with adenomyosis, even with assisted reproduction. According to the current study, endometri...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1435177/full |
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| author | Yuanquan Dai Zheng Yuan Weisen Fan Zhiheng Lin |
| author_facet | Yuanquan Dai Zheng Yuan Weisen Fan Zhiheng Lin |
| author_sort | Yuanquan Dai |
| collection | DOAJ |
| description | Patients with adenomyosis not only experience a decrease in quality of life as a result of dysmenorrhea and severe monthly flow but they are also rendered infertile. Pregnancy rates are still low among women with adenomyosis, even with assisted reproduction. According to the current study, endometrial receptivity is primarily responsible for the lower conception rate among patients with adenomyosis. Decidualization of endometrial stromal cells is the fundamental requirement for endometrial receptivity and the maintenance of a normal pregnancy, even though endometrial receptivity is made up of a variety of cells, including immune cells, endometrial epithelial cells, and endometrial stromal cells. Our overview reveals that endometriosis deficiencies are present in patients with adenomyosis. These flaws may be linked to aberrant pathways in endometrial stromal cells, such as PI3K/Akt, JAK2/STAT3, and hedgehog. Correcting the abnormal expression of molecules in endometrial stromal cells in the endometrium of patients with adenomyosis may become the focus of research to improve endometrial receptivity and increase the pregnancy rate. |
| format | Article |
| id | doaj-art-46f35a8318784b0996e0a8bf476891a4 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-46f35a8318784b0996e0a8bf476891a42025-01-16T05:10:17ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.14351771435177Molecular mechanism of aberrant decidualization in adenomyosis leading to reduced endometrial receptivityYuanquan Dai0Zheng Yuan1Weisen Fan2Zhiheng Lin3Department of Gynecology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaDepartment of Gynecology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaDepartment of Gynecology, Guang anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaPatients with adenomyosis not only experience a decrease in quality of life as a result of dysmenorrhea and severe monthly flow but they are also rendered infertile. Pregnancy rates are still low among women with adenomyosis, even with assisted reproduction. According to the current study, endometrial receptivity is primarily responsible for the lower conception rate among patients with adenomyosis. Decidualization of endometrial stromal cells is the fundamental requirement for endometrial receptivity and the maintenance of a normal pregnancy, even though endometrial receptivity is made up of a variety of cells, including immune cells, endometrial epithelial cells, and endometrial stromal cells. Our overview reveals that endometriosis deficiencies are present in patients with adenomyosis. These flaws may be linked to aberrant pathways in endometrial stromal cells, such as PI3K/Akt, JAK2/STAT3, and hedgehog. Correcting the abnormal expression of molecules in endometrial stromal cells in the endometrium of patients with adenomyosis may become the focus of research to improve endometrial receptivity and increase the pregnancy rate.https://www.frontiersin.org/articles/10.3389/fendo.2024.1435177/fulladenomyosisdecidualizationstromal cellsendometrial receptivitymolecular mechanism |
| spellingShingle | Yuanquan Dai Zheng Yuan Weisen Fan Zhiheng Lin Molecular mechanism of aberrant decidualization in adenomyosis leading to reduced endometrial receptivity Frontiers in Endocrinology adenomyosis decidualization stromal cells endometrial receptivity molecular mechanism |
| title | Molecular mechanism of aberrant decidualization in adenomyosis leading to reduced endometrial receptivity |
| title_full | Molecular mechanism of aberrant decidualization in adenomyosis leading to reduced endometrial receptivity |
| title_fullStr | Molecular mechanism of aberrant decidualization in adenomyosis leading to reduced endometrial receptivity |
| title_full_unstemmed | Molecular mechanism of aberrant decidualization in adenomyosis leading to reduced endometrial receptivity |
| title_short | Molecular mechanism of aberrant decidualization in adenomyosis leading to reduced endometrial receptivity |
| title_sort | molecular mechanism of aberrant decidualization in adenomyosis leading to reduced endometrial receptivity |
| topic | adenomyosis decidualization stromal cells endometrial receptivity molecular mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1435177/full |
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