Evaluation of Acute Dermal Toxicity of Hibiscus Leaves as Simplicial Ointment on Albino Rats
Hibiscus is a plant that has been shown to contain substances that may be used as sunscreen to protect the skin from UV radiation. In terms of their potential as sunscreens, flavonoids, tannins, and quinone chemicals are crucial because they are antioxidants that can reduce the negative effects of U...
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| Format: | Article |
| Language: | English |
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Universitas Airlangga, Faculty of Veterinary Medicine
2023-10-01
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| Series: | Jurnal Medik Veteriner |
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| Online Access: | https://e-journal.unair.ac.id/JMV/article/view/43953 |
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| author | Made Gede Adi Surya Saputra I Wayan Sudira Samsuri Samsuri I Made Merdana Anak Agung Gde Oka Dharmayudha I Gusti Ngurah Sudisma |
| author_facet | Made Gede Adi Surya Saputra I Wayan Sudira Samsuri Samsuri I Made Merdana Anak Agung Gde Oka Dharmayudha I Gusti Ngurah Sudisma |
| author_sort | Made Gede Adi Surya Saputra |
| collection | DOAJ |
| description | Hibiscus is a plant that has been shown to contain substances that may be used as sunscreen to protect the skin from UV radiation. In terms of their potential as sunscreens, flavonoids, tannins, and quinone chemicals are crucial because they are antioxidants that can reduce the negative effects of UV radiation and boost photoprotective activity. This study aimed to investigate the acute dermal toxicity potential of hibiscus leaves simplicial ointment 40% on female albino rats. The evaluation method refered to The OECD Guideline for Testing of Chemicals – No. Test: 402, Acute Dermal Toxicity-Fixed Doses Procedure. Based on the Globally Harmonized System compared to this study reported that acute dermal median lethal dose (LD50) was > 2000 mg/kg. It can be concluded that hibiscus leaves simplicial ointment 40% has safe to apply topically and doesn't produce acute skin toxicity. |
| format | Article |
| id | doaj-art-46f32c0c303447a8b127a418bdbfdb86 |
| institution | Kabale University |
| issn | 2615-7497 2581-012X |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Universitas Airlangga, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Jurnal Medik Veteriner |
| spelling | doaj-art-46f32c0c303447a8b127a418bdbfdb862025-01-02T23:49:45ZengUniversitas Airlangga, Faculty of Veterinary MedicineJurnal Medik Veteriner2615-74972581-012X2023-10-016221622910.20473/jmv.vol6.iss2.2023.216-22942035Evaluation of Acute Dermal Toxicity of Hibiscus Leaves as Simplicial Ointment on Albino RatsMade Gede Adi Surya Saputra0https://orcid.org/0009-0008-4853-1667I Wayan Sudira1https://orcid.org/0000-0002-3651-5386Samsuri Samsuri2https://orcid.org/0000-0003-4377-6653I Made Merdana3https://orcid.org/0000-0001-8944-7658Anak Agung Gde Oka Dharmayudha4https://orcid.org/0000-0003-4990-3019I Gusti Ngurah Sudisma5https://orcid.org/0000-0003-4990-3019Veterinary Medicine Study Program, Faculty of Veterinary Medicine, Udayana University, Denpasar, BaliVeterinary Physiology, Pharmacy and Pharmacology Laboratory, Faculty of Veterinary Medicine, Udayana University, Denpasar, BaliVeterinary Physiology, Pharmacy and Pharmacology Laboratory, Faculty of Veterinary Medicine, Udayana University, Denpasar, BaliVeterinary Physiology, Pharmacy and Pharmacology Laboratory, Faculty of Veterinary Medicine, Udayana University, Denpasar, BaliVeterinary Clinic Department, Faculty of Veterinary Medicine, Udayana University, Denpasar, BaliVeterinary Clinic Department, Faculty of Veterinary Medicine, Udayana University, Denpasar, BaliHibiscus is a plant that has been shown to contain substances that may be used as sunscreen to protect the skin from UV radiation. In terms of their potential as sunscreens, flavonoids, tannins, and quinone chemicals are crucial because they are antioxidants that can reduce the negative effects of UV radiation and boost photoprotective activity. This study aimed to investigate the acute dermal toxicity potential of hibiscus leaves simplicial ointment 40% on female albino rats. The evaluation method refered to The OECD Guideline for Testing of Chemicals – No. Test: 402, Acute Dermal Toxicity-Fixed Doses Procedure. Based on the Globally Harmonized System compared to this study reported that acute dermal median lethal dose (LD50) was > 2000 mg/kg. It can be concluded that hibiscus leaves simplicial ointment 40% has safe to apply topically and doesn't produce acute skin toxicity.https://e-journal.unair.ac.id/JMV/article/view/43953acute dermal toxicityhibiscusointment |
| spellingShingle | Made Gede Adi Surya Saputra I Wayan Sudira Samsuri Samsuri I Made Merdana Anak Agung Gde Oka Dharmayudha I Gusti Ngurah Sudisma Evaluation of Acute Dermal Toxicity of Hibiscus Leaves as Simplicial Ointment on Albino Rats Jurnal Medik Veteriner acute dermal toxicity hibiscus ointment |
| title | Evaluation of Acute Dermal Toxicity of Hibiscus Leaves as Simplicial Ointment on Albino Rats |
| title_full | Evaluation of Acute Dermal Toxicity of Hibiscus Leaves as Simplicial Ointment on Albino Rats |
| title_fullStr | Evaluation of Acute Dermal Toxicity of Hibiscus Leaves as Simplicial Ointment on Albino Rats |
| title_full_unstemmed | Evaluation of Acute Dermal Toxicity of Hibiscus Leaves as Simplicial Ointment on Albino Rats |
| title_short | Evaluation of Acute Dermal Toxicity of Hibiscus Leaves as Simplicial Ointment on Albino Rats |
| title_sort | evaluation of acute dermal toxicity of hibiscus leaves as simplicial ointment on albino rats |
| topic | acute dermal toxicity hibiscus ointment |
| url | https://e-journal.unair.ac.id/JMV/article/view/43953 |
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